Hydrogels and Microgels: Driving Revolutionary Innovations in Targeted Drug Delivery, Strengthening Infection Management, and Advancing Tissue Repair and Regeneration

Gels, Journal Year: 2025, Volume and Issue: 11(3), P. 179 - 179

Published: March 3, 2025

Hydrogels and microgels are emerging as pivotal platforms in biomedicine, with significant potential targeted drug delivery, enhanced infection management, tissue repair regeneration. These gels, characterized by their high water content, unique structures, adaptable mechanical properties, interact seamlessly biological systems, making them invaluable for controlled release. In the realm of hydrogels can incorporate antimicrobial agents, offering robust defenses against bacterial infections. This capability is increasingly important fight antibiotic resistance, providing innovative solutions prevention wound dressings, surgical implants, medical devices. Additionally, biocompatibility customizable properties these gels make ideal scaffolds engineering, supporting growth damaged tissues. Despite promising applications, challenges such ensuring long-term stability, enhancing therapeutic agent loading capacities, scaling production must be addressed widespread adoption. review explores current advancements, opportunities, limitations microgels, highlighting research technological directions poised to revolutionize treatment strategies through personalized regenerative approaches.

Language: Английский

Advances in Hydrogels of Drug Delivery Systems for Local Treatment of Brain Tumors

Published: May 22, 2024

The management of brain tumors presents numerous challenges, despite the employment multimodal therapies including surgical intervention, radiotherapy, chemotherapy, and immunotherapy. Owing to distinct location presence blood-brain barrier (BBB), these exhibit considerable heterogeneity invasiveness at a histological level. Recent advancements in hydrogel research for local treatment have sought overcome primary challenge delivering therapeutics past BBB, thereby ensuring efficient accumulation within tumor tissues. This article elaborates on various hydrogel-based delivery vectors, examining their efficacy tumors. Additionally, it reviews fundamental principles involved designing intelligent hydrogels that can circumvent BBB penetrate larger areas, facilitating precise, controlled drug release. Hydrogel-based systems (DDSs) are posited offer groundbreaking approach addressing challenges limitations inherent traditional oncological therapies, which significantly impeded by unique structural pathological characteristics

Language: Английский