Risk Stratification for Future Cardiac Arrest after COVID-19 Vaccination DOI Open Access
Peter A. McCullough, Nicolas Hulscher

Published: Aug. 12, 2024

Unheralded cardiac arrest among previously healthy young people without antecedent illness, months or years after COVID-19 vaccination, highlights the urgent need for risk stratification. The most likely underlying pathophysiology is subclinical myopericarditis and reentrant ventricular tachycardia spontaneous fibrillation that commonly precipitated a surge in catecholamines during exercise waking hours of terminal sleep. Small patches inflammation and/or edema can be missed on imaging autopsy, heart appear grossly normal. This paper reviews evidence linking vaccines to where unfortunately majority victims have had no clinical evaluation. We propose comprehensive strategy evaluating cardiovascular post-vaccination, incorporating detailed patient history, antibody testing, diagnostics best attempt detect abnormalities before sudden death. approach aims identify individuals at higher events vaccination guide appropriate management. It prudent each primary care physician pre-established plan when addressing this issue their practice.

Language: Английский

Risk stratification for future cardiac arrest after COVID-19 vaccination DOI Open Access

Peter A McCullough,

Nicolas Hulscher

World Journal of Cardiology, Journal Year: 2025, Volume and Issue: 17(2)

Published: Feb. 24, 2025

Unheralded cardiac arrest among previously healthy young people without antecedent illness, months or years after coronavirus disease 2019 (COVID-19) vaccination, highlights the urgent need for risk stratification. The most likely underlying pathophysiology is subclinical myopericarditis and reentrant ventricular tachycardia spontaneous fibrillation that commonly precipitated a surge in catecholamines during exercise waking hours of terminal sleep. Small patches inflammation and/or edema can be missed on imaging autopsy, heart appear grossly normal. This paper reviews evidence linking COVID-19 vaccines to where unfortunately majority victims have had no clinical evaluation. We propose comprehensive strategy evaluating cardiovascular post-vaccination, incorporating detailed patient history, antibody testing, diagnostics best attempt detect abnormalities before sudden death. approach aims identify individuals at higher events vaccination guide appropriate management. It prudent each primary care physician pre-established plan when addressing this issue their practice.

Language: Английский

Citations

0
COVID‐19 vaccine adverse events: Evaluating the pathophysiology with an emphasis on sulfur metabolism and endotheliopathy DOI Creative Commons
Heidi N. du Preez, Johnson Lin, Glenn E. M. Maguire

et al.

European Journal of Clinical Investigation, Journal Year: 2024, Volume and Issue: 54(10)

Published: Aug. 8, 2024

Abstract In this narrative review, we assess the pathophysiology of severe adverse events that presented after vaccination with DNA and mRNA vaccines against COVID‐19. The focus is on perspective an undersulfated degraded glycocalyx, considering its impact immunomodulation, inflammatory responses, coagulation oxidative stress. paper explores various factors lead to glutathione inorganic sulfate depletion their subsequent effect glycocalyx sulfation other metabolites, including hormones. Components COVID‐19 vaccines, such as material, spike protein antigen lipid nanoparticles, are involved in possible cytotoxic effects. common thread connecting these endotheliopathy or degradation, caused by depleted levels, shear stress from circulating aggregation formation coronas; leading imbalanced immune responses chronic release pro‐inflammatory cytokines, ultimately resulting systemic response syndrome. By understanding underlying events, better treatment options can be explored.

Language: Английский

Citations

1
Risk Stratification for Future Cardiac Arrest after COVID-19 Vaccination DOI Open Access
Peter A. McCullough, Nicolas Hulscher

Published: Aug. 12, 2024

Unheralded cardiac arrest among previously healthy young people without antecedent illness, months or years after COVID-19 vaccination, highlights the urgent need for risk stratification. The most likely underlying pathophysiology is subclinical myopericarditis and reentrant ventricular tachycardia spontaneous fibrillation that commonly precipitated a surge in catecholamines during exercise waking hours of terminal sleep. Small patches inflammation and/or edema can be missed on imaging autopsy, heart appear grossly normal. This paper reviews evidence linking vaccines to where unfortunately majority victims have had no clinical evaluation. We propose comprehensive strategy evaluating cardiovascular post-vaccination, incorporating detailed patient history, antibody testing, diagnostics best attempt detect abnormalities before sudden death. approach aims identify individuals at higher events vaccination guide appropriate management. It prudent each primary care physician pre-established plan when addressing this issue their practice.

Language: Английский

Citations

1