Relationship of Metabolic Dysfunction-associated Steatohepatitis-related Hepatocellular Carcinoma with Oral and Intestinal Microbiota: A Cross-Sectional Pilot Study DOI Open Access
Takaaki Matsui, Toshiya Morozumi, Yuko Yamamoto

et al.

Published: June 11, 2024

Background: The incidence of metabolic dysfunction-associated steatohepatitis (MASH)-related hepatocellular carcinoma (HCC) is increasing annually with a rise in the obesity and syndrome. Based on preliminary reports regarding potential association HCC periodontitis, this study aimed to analyze involvement periodontal bacteria as well oral intestinal bacterial flora MASH-related (MASH-HCC). Methods: Forty-one patients MASH 19 MASH-HCC who completed survey questionnaires, underwent examinations, subjected sample collection (saliva, mouth-rinsed water, feces, peripheral blood) participated study. Bayesian network analysis was used causation between various factors, including MASH-HCC, bacteria. Results: occupancy rate genus Fusobacterium significantly higher group than (p = 0.002), whereas that Butyricicoccus 0.022) Roseburia < 0.05) lower. revealed absence pathogenic enteric affecting HCC. However, directly affected species Porphyromonas gingivalis, Tannerella forsythia, nucleatum, Prevotella intermedia saliva, genera Lactobacillus, Roseburia, Fusobacterium, Prevotella, Clostridium, Ruminococcus, Trabulsiella, SMB53 intestine. Furthermore, P. gingivalis cavity Lactobacillus Streptococcus Conclusion: affects bacteria, may affect associated gastrointestinal cancer.

Language: Английский

Relationship of Metabolic Dysfunction-associated Steatohepatitis-related Hepatocellular Carcinoma with Oral and Intestinal Microbiota: A Cross-Sectional Pilot Study DOI Open Access
Takaaki Matsui, Toshiya Morozumi, Yuko Yamamoto

et al.

Published: June 11, 2024

Background: The incidence of metabolic dysfunction-associated steatohepatitis (MASH)-related hepatocellular carcinoma (HCC) is increasing annually with a rise in the obesity and syndrome. Based on preliminary reports regarding potential association HCC periodontitis, this study aimed to analyze involvement periodontal bacteria as well oral intestinal bacterial flora MASH-related (MASH-HCC). Methods: Forty-one patients MASH 19 MASH-HCC who completed survey questionnaires, underwent examinations, subjected sample collection (saliva, mouth-rinsed water, feces, peripheral blood) participated study. Bayesian network analysis was used causation between various factors, including MASH-HCC, bacteria. Results: occupancy rate genus Fusobacterium significantly higher group than (p = 0.002), whereas that Butyricicoccus 0.022) Roseburia < 0.05) lower. revealed absence pathogenic enteric affecting HCC. However, directly affected species Porphyromonas gingivalis, Tannerella forsythia, nucleatum, Prevotella intermedia saliva, genera Lactobacillus, Roseburia, Fusobacterium, Prevotella, Clostridium, Ruminococcus, Trabulsiella, SMB53 intestine. Furthermore, P. gingivalis cavity Lactobacillus Streptococcus Conclusion: affects bacteria, may affect associated gastrointestinal cancer.

Language: Английский

Citations

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