Published: June 25, 2024
Parkinson’s disease (PD) is a common multisystem neurodegenerative disorder affecting 1% of the population above 60 years. The main neuropathological features PD are loss dopaminergic neurons in substantia nigra pars compacta (SNpc) and presence alpha synuclein (Syn)-rich Lewy bodies both manifesting with classical motor signs. Syn has emerged as key protein pathology it can spread through synaptic networks to reach several anatomical regions body contributing appearance non-motor symptoms (NMS) considerate prevalent among individuals before diagnosis persisting throughout patient’s life. NMS mainly include taste smell, constipation, psychiatric disorders, dementia, rapid eye movement (REM) sleep behavior impairment, urogenital dysfunction, cardiovascular impairment. This review summarizes more recent findings showing impact deposits on prodromal emphasizes importance early detection toxic species biofluids peripheral biopsies prospective biomarkers PD.
Language: Английский