Advancements in Ocular Therapy: A Review of Emerging Drug Delivery Approaches and Pharmaceutical Technologies DOI Creative Commons
Bhupendra Raj Giri,

Deeksha Jakka,

Michael A. Sandoval

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(10), P. 1325 - 1325

Published: Oct. 12, 2024

Eye disorders affect a substantial portion of the global population, yet availability efficacious ophthalmic drug products remains limited. This can be partly ascribed to number factors: (1) inadequate understanding physiological barriers, treatment strategies, and polymer properties, delivery systems; (2) challenges in effectively delivering drugs anterior posterior segments eye due anatomical constraints; (3) manufacturing regulatory hurdles ocular product development. The present review discusses innovative treatments, encompassing implants, liposomes, nanoparticles, nanomicelles, microparticles, iontophoresis, situ gels, contact lenses, microneedles, hydrogels, bispecific antibodies, gene strategies. Furthermore, this also introduces advanced technologies such as 3D printing hot-melt extrusion (HME), aimed at improving bioavailability, reducing therapeutic dosages side effects, facilitating design personalized dosage forms, well enhancing patient compliance. comprehensive lastly offers insights into digital healthcare, market trends, industry perspectives pertaining

Language: Английский

Advancements in Ocular Therapy: A Review of Emerging Drug Delivery Approaches and Pharmaceutical Technologies DOI Creative Commons
Bhupendra Raj Giri,

Deeksha Jakka,

Michael A. Sandoval

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(10), P. 1325 - 1325

Published: Oct. 12, 2024

Eye disorders affect a substantial portion of the global population, yet availability efficacious ophthalmic drug products remains limited. This can be partly ascribed to number factors: (1) inadequate understanding physiological barriers, treatment strategies, and polymer properties, delivery systems; (2) challenges in effectively delivering drugs anterior posterior segments eye due anatomical constraints; (3) manufacturing regulatory hurdles ocular product development. The present review discusses innovative treatments, encompassing implants, liposomes, nanoparticles, nanomicelles, microparticles, iontophoresis, situ gels, contact lenses, microneedles, hydrogels, bispecific antibodies, gene strategies. Furthermore, this also introduces advanced technologies such as 3D printing hot-melt extrusion (HME), aimed at improving bioavailability, reducing therapeutic dosages side effects, facilitating design personalized dosage forms, well enhancing patient compliance. comprehensive lastly offers insights into digital healthcare, market trends, industry perspectives pertaining

Language: Английский

Citations

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