Is Deuterium Fractionation a Major Controlling Factor in Human Metabolism and Cancer? An Essential Role for Proline DOI Open Access
Stephanie Seneff

Published: June 19, 2024

Deuterium is a heavy nonradioactive isotope of hydrogen, having neutron as well proton, making it twice heavy. It natural element, present at 156 parts per million in seawater. The ATPase pumps the mitochondria utilize proton motive force to drive ATP synthesis, and deuterons damage pumps, producing stutter that can cause reactive oxygen release inefficiencies synthesis. Cellular metabolism incorporates several novel mechanisms assure low deuterium content other organelles. Nicotinamide adenine dinucleotide (NAD) major carrier depleted (deupleted) protons supply mitochondria. Many enzymes, especially flavoproteins, are able use tunneling fractionate out deuterium. In this paper, we argue amino acid proline trap sequester deuterium, peptidyl prolyl isomerases (PPIases) play central role facilitating trapping proline-rich proteins, most notably collagen. endothelial glycocalyx also sequesters gelled water lining blood vessels, creating battery promoting circulation. Excess promotes cancer growth, cells large quantities lactate via aerobic glycolysis help reverse overload, systemically.

Language: Английский

Is Deuterium Fractionation a Major Controlling Factor in Human Metabolism and Cancer? An Essential Role for Proline DOI Open Access
Stephanie Seneff

Published: June 19, 2024

Deuterium is a heavy nonradioactive isotope of hydrogen, having neutron as well proton, making it twice heavy. It natural element, present at 156 parts per million in seawater. The ATPase pumps the mitochondria utilize proton motive force to drive ATP synthesis, and deuterons damage pumps, producing stutter that can cause reactive oxygen release inefficiencies synthesis. Cellular metabolism incorporates several novel mechanisms assure low deuterium content other organelles. Nicotinamide adenine dinucleotide (NAD) major carrier depleted (deupleted) protons supply mitochondria. Many enzymes, especially flavoproteins, are able use tunneling fractionate out deuterium. In this paper, we argue amino acid proline trap sequester deuterium, peptidyl prolyl isomerases (PPIases) play central role facilitating trapping proline-rich proteins, most notably collagen. endothelial glycocalyx also sequesters gelled water lining blood vessels, creating battery promoting circulation. Excess promotes cancer growth, cells large quantities lactate via aerobic glycolysis help reverse overload, systemically.

Language: Английский

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