Published: June 19, 2024

Understanding and preventing the “great obstetrical syndromes” has been focus of pregnancy research for decades. The combined global impact from these syndromes on maternal perinatal morbidity mortality is compounded by increased long-term risk adverse health effects following pregnancy. Accumulating evidence indicates that conditions such as pre-eclampsia, fetal growth restriction, spontaneous preterm labour, stillbirth, are with etiologic heterogeneity share common pathophysiologic pathways involving placental dysfunction. Recently, importance interaction between genomes extended to include epigenetic pre-existing pathophysiology development highlights nutritional environmental factors in altered placentation. Validated first-trimester screening algorithms preeclampsia can identify high-risk women prophylactic treatment low-dose aspirin be initiated. High-risk monitored during second trimester using clinical assessment, ultrasound, biochemical markers, able predict complications prior signs symptoms. integration lifestyle interventions, screening, medical management represents a conceptual advance care. This approach potential significantly reduce complications, mortality, outcomes later life, health-care costs.

Language: Английский