Lamiaceae Plants and Cardiovascular Health: A Patent-Driven Path to Functional Foods DOI Creative Commons
Reda El Boukhari, Ahmed Fatimi

Foods, Journal Year: 2024, Volume and Issue: unknown, P. 2 - 2

Published: Dec. 12, 2024

The Lamiaceae family of medicinal plants holds immense promise in the development functional foods aimed at preventing and treating cardiovascular diseases (CVDs). These are rich bioactive compounds, such as phenolic acids, flavonoids, terpenoids, which act potent enzyme inhibitors exhibit strong antioxidant, anti-inflammatory, antihyperlipidemic properties. Key rosmarinic acid caffeic acid, along with flavonoids like luteolin, apigenin, quercetin, contribute to these health benefits. Essential oils derived from species have demonstrated diverse biological activities, including vasorelaxant, thrombolytic, cytotoxic effects, making them valuable nutraceutical formulations. This study analyzes investigates global patent trends related targeting health, focusing on applications nutraceuticals foods. Using databases, we examine technological landscape, identify leading applicants, evaluate geographical distribution innovations. Our analysis reveals a notable increase filings since late 1970s, peaking 2007, indicating growing interest leveraging for health. Tianjin Tasly Pharmaceuticals Co., Ltd. emerges applicant, reflecting active engagement by pharmaceutical companies alongside independent researchers organizations. Geographically, China leads activity, followed United States Europe, underscoring market potential. International Patent Classification (IPC) codes identified include A61K36/53 (Lamiaceae extracts), A61P9/00 (cardiovascular drugs), A61P9/10 (treatments ischemic or atherosclerotic diseases). findings highlight therapeutic commercial relevance bioactives, offering insights into their potential advancing shaping future food industries.

Language: Английский

Caralluma fimbriata Extract Improves Vascular Dysfunction in Obese Mice Fed a High-Fat Diet DOI Open Access
V. B. S. C. Thunuguntla, Laura Kate Gadanec,

C. McGrath

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(24), P. 4296 - 4296

Published: Dec. 12, 2024

Background: Obesity is a risk factor for developing cardiovascular diseases (CVDs) by impairing normal vascular function. Natural products are gaining momentum in the clinical setting due to their high efficacy and low toxicity. Caralluma fimbriata extract (CFE) has been shown control appetite promote weight loss; however, its effect on function remains poorly understood. This study aimed determine that CFE had loss mice fed high-fat diet (HFD) induce obesity, comparing this of lorcaserin (LOR) (an anti-obesity pharmaceutical) treatment. Methods: C57BL/6J male (n = 80) were 16-week HFD obesity prior being treated with LOR as standalone treatments or conjunction. Body composition data, such gain fat mass content measured, isometric tension analyses performed isolated abdominal aortic rings relaxation responses acetylcholine, immunohistochemistry studies utilized expression profiles endothelial nitric oxide synthase (eNOS) cell stress markers (nitrotyrosine (NT) 78 kDa glucose-regulated protein (GRP78)) endothelial, medial adventitial layers rings. Results: The results demonstrated + significantly reduced (17%; 24%) deposition (14%; 16%). A markedly acetylcholine-mediated (p < 0.05, p 0.0001) eNOS 0.0001, 0.01) increased NT GRP78 0.01, 0.001). Obese exhibited improved ACh-induced responses, expression. Conclusions: Thus, alone combination could serve an alternative strategy preventing obesity-related diseases.

Language: Английский

Citations

0
Lamiaceae Plants and Cardiovascular Health: A Patent-Driven Path to Functional Foods DOI Creative Commons
Reda El Boukhari, Ahmed Fatimi

Foods, Journal Year: 2024, Volume and Issue: unknown, P. 2 - 2

Published: Dec. 12, 2024

The Lamiaceae family of medicinal plants holds immense promise in the development functional foods aimed at preventing and treating cardiovascular diseases (CVDs). These are rich bioactive compounds, such as phenolic acids, flavonoids, terpenoids, which act potent enzyme inhibitors exhibit strong antioxidant, anti-inflammatory, antihyperlipidemic properties. Key rosmarinic acid caffeic acid, along with flavonoids like luteolin, apigenin, quercetin, contribute to these health benefits. Essential oils derived from species have demonstrated diverse biological activities, including vasorelaxant, thrombolytic, cytotoxic effects, making them valuable nutraceutical formulations. This study analyzes investigates global patent trends related targeting health, focusing on applications nutraceuticals foods. Using databases, we examine technological landscape, identify leading applicants, evaluate geographical distribution innovations. Our analysis reveals a notable increase filings since late 1970s, peaking 2007, indicating growing interest leveraging for health. Tianjin Tasly Pharmaceuticals Co., Ltd. emerges applicant, reflecting active engagement by pharmaceutical companies alongside independent researchers organizations. Geographically, China leads activity, followed United States Europe, underscoring market potential. International Patent Classification (IPC) codes identified include A61K36/53 (Lamiaceae extracts), A61P9/00 (cardiovascular drugs), A61P9/10 (treatments ischemic or atherosclerotic diseases). findings highlight therapeutic commercial relevance bioactives, offering insights into their potential advancing shaping future food industries.

Language: Английский

Citations

0