Use of Cosmetics in Pregnancy and Neurotoxicity: Increased Risk of Congenital Enteric Neuropathies DOI Open Access

Kendra Jones,

Lucas M. Wessel, Karl‐Herbert Schäfer

et al.

Published: July 4, 2024

The inclusion of various chemical substances in personal care products (PCPs) and cosmetic formulations can be associated with disruption damage to the nervous system. Microplastics, benzophenones, parabens, phthalates metals are among most common found cosmetics that have been shown induce neurotoxic mechanisms. Although neurotoxin exposure is believed minimal, different scenarios suggest these neurotoxins remain a threat. Special attention should paid early first gestation weeks, when critical processes, like migration proliferation neural crest derived cells start form ENS. Importantly, cosmetic’s cross placenta barrier so affect future embryo, but also secreted breast milk, babies exposed for longer periods, even after birth. In this review we explore how contained PCPs may role pathogenesis neurodevelopment disorders neurodegenerative diseases, therefore congenital enteric aganglionosis as well postnatal motility disorders. Understanding mechanisms chemicals used their neurotoxicity crucial determining safety use during pregnancy.

Language: Английский

Use of Cosmetics in Pregnancy and Neurotoxicity: Increased Risk of Congenital Enteric Neuropathies DOI Open Access

Kendra Jones,

Lucas M. Wessel, Karl‐Herbert Schäfer

et al.

Published: July 4, 2024

The inclusion of various chemical substances in personal care products (PCPs) and cosmetic formulations can be associated with disruption damage to the nervous system. Microplastics, benzophenones, parabens, phthalates metals are among most common found cosmetics that have been shown induce neurotoxic mechanisms. Although neurotoxin exposure is believed minimal, different scenarios suggest these neurotoxins remain a threat. Special attention should paid early first gestation weeks, when critical processes, like migration proliferation neural crest derived cells start form ENS. Importantly, cosmetic’s cross placenta barrier so affect future embryo, but also secreted breast milk, babies exposed for longer periods, even after birth. In this review we explore how contained PCPs may role pathogenesis neurodevelopment disorders neurodegenerative diseases, therefore congenital enteric aganglionosis as well postnatal motility disorders. Understanding mechanisms chemicals used their neurotoxicity crucial determining safety use during pregnancy.

Language: Английский

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