Image-Guided Mesenchymal Stem Cell Sodium Iodide Symporter (NIS) Radionucleotide Therapy for Glioblastoma DOI Open Access
Siddharth Shah, Brandon Lucke‐Wold

Published: July 9, 2024

Background: Glioblastoma (GBM) is a highly aggressive, invasive, and growth-factor-independent grade IV glioma. Survival following the diagnosis generally poor, with median survival of approximately 15 months, it considered most aggressive lethal central nervous system tumor. Conventional treatments based on surgery, chemotherapy, radiation therapy only delay progression, death inevitable. Malignant glioma cells are resistant to traditional therapies, potentially due subpopulation stem that invasive capable rapid regrowth. Methods: Systematic retrieval information was performed PubMed. Specified keywords were used in PubMed articles published peer-reviewed scientific journals associated brain GBM cancer, sodium iodide symporter (NIS). Additionally, words 'radionuclide therapy', 'radioiodine', 'iodine-131', 'molecular imaging', 'gene 'translational imaging' used. Other such as ‘glioblastoma', 'targeted', 'theranostic', 'symporter', 'virus', 'solid tumor', 'combined 'pituitary', or 'plasmid' also appropriate literature databases search engines. 19 found this Mesenchymal Stem Cell Sodium Iodide Symporter GBM. \ These from years 2000 2024. Appropriate studies isolated, important each them understood entered into database which article. Results: For long they express functional NIS, mesenchymal systemically repress T B cells; however, after that, largely replaced by generated embryonic functionally competent. As result their natural capacity identify malignancies, MSC employed tumor vehicles. Because MSCs may be transplanted several methods, have been proposed ideal vehicles for NIS gene transfer. Conclusion: Non-invasive imaging-based detection presents an alternate means monitor diagnose evaluate recurrence. The iodine specific variety human thyroid disease functions move cell. In recent years, increasing number related reported tumors therapeutic vectors imaging therapy. Gene nuclear medicine provide new direction.

Language: Английский

Mesenchymal Stem Cell-Derived Exosomes as a Neuroregeneration Treatment for Alzheimer’s Disease DOI Creative Commons
Siddharth Shah, Hadeel M. Mansour,

Tania M. Aguilar

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(9), P. 2113 - 2113

Published: Sept. 17, 2024

Background: Alzheimer’s disease (AD) is the most prevalent kind of dementia and a long-term degenerative disease. Pathologically, it defined by development extracellular amyloid-β plaques intracellular neurofibrillary tangles made up hyperphosphorylated tau protein. This causes neuronal death, particularly in hippocampus cortex. Mesenchymal stem cell (MSC)-derived exosomes have been identified as possibly therapeutic promise for due to their regenerative characteristics. Methods: A systematic retrieval information was performed on PubMed. total 60 articles were found search mesenchymal cells, exosomes, 16 ongoing clinical trials searched added from clinicaltrials.gov. We 23 supporting help provide certain sections. In total, we included 99 this manuscript: 50 are review articles, 13 preclinical studies, trials, 4 observational studies. Appropriate studies isolated, important each them understood entered into database which used article. The Results: Several experimental investigations shown that MSC-Exo improves cognitive impairment rats. paper, summarized existing understanding regarding molecular cellular pathways behind MSC-Exo-based function restoration, with focus MSC-Exo’s potential treatment Conclusion: AD significant health issue our culture linked several neuropathological Exosomes generated such cells (MSCs) or neural (NSCs), examined more variety models, indicating they may be viable agents diverse disorders. Exosome yields increased, efficacy can improved using range tailored techniques conditions. It necessary standardized guidelines exosome manufacture carry out excellent research.

Language: Английский

Citations

5
Ovarian cancer: Advances in clinical research DOI

Mahendra Saini,

Nidhi Chauhan, Afrasim Moin

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 221 - 250

Published: Jan. 1, 2025

Language: Английский

Citations

0
Image-Guided Mesenchymal Stem Cell Sodium Iodide Symporter (NIS) Radionucleotide Therapy for Glioblastoma DOI Open Access
Siddharth Shah, Brandon Lucke‐Wold

Published: July 9, 2024

Background: Glioblastoma (GBM) is a highly aggressive, invasive, and growth-factor-independent grade IV glioma. Survival following the diagnosis generally poor, with median survival of approximately 15 months, it considered most aggressive lethal central nervous system tumor. Conventional treatments based on surgery, chemotherapy, radiation therapy only delay progression, death inevitable. Malignant glioma cells are resistant to traditional therapies, potentially due subpopulation stem that invasive capable rapid regrowth. Methods: Systematic retrieval information was performed PubMed. Specified keywords were used in PubMed articles published peer-reviewed scientific journals associated brain GBM cancer, sodium iodide symporter (NIS). Additionally, words 'radionuclide therapy', 'radioiodine', 'iodine-131', 'molecular imaging', 'gene 'translational imaging' used. Other such as ‘glioblastoma', 'targeted', 'theranostic', 'symporter', 'virus', 'solid tumor', 'combined 'pituitary', or 'plasmid' also appropriate literature databases search engines. 19 found this Mesenchymal Stem Cell Sodium Iodide Symporter GBM. \ These from years 2000 2024. Appropriate studies isolated, important each them understood entered into database which article. Results: For long they express functional NIS, mesenchymal systemically repress T B cells; however, after that, largely replaced by generated embryonic functionally competent. As result their natural capacity identify malignancies, MSC employed tumor vehicles. Because MSCs may be transplanted several methods, have been proposed ideal vehicles for NIS gene transfer. Conclusion: Non-invasive imaging-based detection presents an alternate means monitor diagnose evaluate recurrence. The iodine specific variety human thyroid disease functions move cell. In recent years, increasing number related reported tumors therapeutic vectors imaging therapy. Gene nuclear medicine provide new direction.

Language: Английский

Citations

3