Genomic Evolution and Phylodynamics of the Species Orthomarburgvirus marburgense (Marburg and Ravn Viruses) to Understand Viral Adaptation and Marburg Virus Disease’s Transmission Dynamics DOI Creative Commons
Claude Mambo Muvunyi, Nouh Saad Mohamed, Emmanuel Edwar Siddig

et al.

Pathogens, Journal Year: 2024, Volume and Issue: 13(12), P. 1107 - 1107

Published: Dec. 14, 2024

In this review, we investigated the genetic diversity and evolutionary dynamics of Orthomarburgvirus marburgense species that includes both Marburg virus (MARV) Ravn (RAVV). Using sequence data from natural reservoir hosts human cases reported during outbreaks, conducted comprehensive analyses to explore variability, constructing haplotype networks at genome gene levels elucidate viral pathways. Our results revealed distinct trajectories for MARV RAVV, with exhibiting higher adaptability across different ecological regions. showed substantial evidence varied pressures, suggesting an ability adapt diverse environments. contrast, RAVV demonstrated limited diversity, no detected recombination events, stability. These differences indicate that, while continues diversify regions, may be constrained in its potential, possibly reflecting differing roles within ecology species. analysis explains mechanisms these viruses, highlighting is going through adaptation human-to-human transmission, alarmingly underscoring global concern about causing next pandemic. However, further transdisciplinary One Health research warranted answer some remaining questions including host range susceptibility domestic wildlife as well role biodiversity network disease’s dynamics.

Language: Английский

Rift Valley Fever in Rwanda Is Urging for Enhancing Global Health Security Through Multisectoral One Health Strategy DOI Creative Commons
Claude Mambo Muvunyi, Jean Claude Semuto Ngabonziza, Emmanuel Edwar Siddig

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(1), P. 91 - 91

Published: Jan. 5, 2025

Rift Valley fever (RVF) is a devastating zoonotic mosquito-borne viral hemorrhagic disease that threats human and animal health biodiversity in Africa, including Rwanda. RVF increasingly outbreaking leading to impacts on health, socioeconomic stability growth, food insecurity the region, particularly among livestock-dependent communi-ties. This systematic review synthesizes existing evidence RVF's epidemiology, transmission dynamics, prevention control measures implemented Our findings high-light rapidly increasing prevalence of expansion its geographical distribution host range Furthermore, reveals gaps local evidence, existence competent vectors RVFV risk factors associated with emergence spread country. underscores urgent need for prospective research inform evidence-based policymaking, strategic planning, development implementation cost-effective preventive measures, diagnosis surveillance early detection response. It also calls institutionalization cost-effective, multisectoral, transdisciplinary One Health strategy reducing burden climate climate-sensitive diseases, RVF, We recommend exploring and/or vaccination mechanisms integrating AI-powered drones into dis-ease control, routine genomics-enhanced xenosurveillance monitor changes pathogens dynamics order poli-cymaking guide interventions.

Language: Английский

Citations

1
The Mpox Response Among Key Populations at High Risk of or Living with HIV in Rwanda: Leveraging the Successful National HIV Control Program for More Impactful Interventions DOI Creative Commons
Gallican N. Rwibasira, Tafadzwa Dzinamarira, Jean Claude Semuto Ngabonziza

et al.

Vaccines, Journal Year: 2025, Volume and Issue: 13(3), P. 307 - 307

Published: March 13, 2025

Mpox, an emerging zoonotic infectious disease, presents a significant public health threat, especially among high-risk groups like female sex workers and men who have with men. This commentary reviews summarizes Rwanda’s response to mpox, focusing on its intersection HIV. Rwanda has adopted integrated strategy tackle both mpox HIV by leveraging lessons experience from the country’s success in management of COVID-19, enhancing community engagement outcomes. To ensure long-term resilience, must continue invest surveillance research, expand vaccination efforts, address stigma, foster regional impactful partnerships. Investing fostering scientific operational research will generate invaluable evidence that could lead implementation evidence-based policymaking cost-effective interventions.

Language: Английский

Citations

0
A diagnostic challenge of tongue botryomycosis miming mycetoma—A case report DOI Creative Commons
Emmanuel Edwar Siddig, Ayman Ahmed

Skin Health and Disease, Journal Year: 2024, Volume and Issue: 4(5)

Published: Aug. 5, 2024

Abstract Botryomycosis of the tongue is a rare chronic bacterial infection that presents as nodular masses, mimicking other infectious or neoplastic conditions such mycetoma. A case an 80‐year‐old male was presented with painless swelling on right lateral side his to outpatient clinic. Biopsy and microbiological investigations revealed unexpected Staphylococcus aureus ‐related botryomycosis. This highlights diagnostic challenge for unusual clinical presentations infections. Healthcare providers in countries endemic diseases manifest similarly should investigate thoroughly ensure positive outcome through early diagnosis effective management.

Language: Английский

Citations

3
Diversity, Distribution, and Resistance Profiles of Bacterial Bloodstream Infections in Three Tertiary Referral Hospitals in Rwanda between 2020 and 2022 DOI Open Access
Misbah Gashegu, Vedaste Ndahindwa, Edson Rwagasore

et al.

Published: July 22, 2024

The burden of bacterial bloodstream infections (BSIs) is rapidly increasing in Africa including Rwanda. This a retrospective study investigates the diversity, distribution, and antimicrobial susceptibility profiles BSIs bacteria three tertiary referral hospitals Rwanda between 2020 2022. A total 1,532 blood culture tests were performed for visiting patients. Overall, proportions Gram-negative Gram-positive 48.2% 51.8, respectively. Staphylococcus aureus was predominant species accounting 25% all Klebsiella representing 41% species. Antimicrobial testing revealed that Amikacin exhibited highest activity against Enterobacter spp., Serratia spp. Escherichia coli >92% cases 75.7%. Meropenem Imipenem highly efficacious to Salmonella (100% susceptibility), (96.2% 91.7%, respectively), (94.7% 95.5%, respectively). Enterococcus S. aureus, Streptococcus Vancomycin 100%, 99.5% 97.1%, sensitive Colistin (98.7%), Polymyxin B (85.6%), (84.9%), (78.5%). We recommend strengthening implementation integrated transdisciplinary multisectoral One Health AMR-stewardship surveillance, prevention, control AMR

Language: Английский

Citations

2
Genomic Evolution and Phylodynamics of the Species Orthomarburgvirus marburgense (Marburg and Ravn Viruses) to Understand Viral Adaptation and Marburg Virus Disease’s Transmission Dynamics DOI Creative Commons
Claude Mambo Muvunyi, Nouh Saad Mohamed, Emmanuel Edwar Siddig

et al.

Pathogens, Journal Year: 2024, Volume and Issue: 13(12), P. 1107 - 1107

Published: Dec. 14, 2024

In this review, we investigated the genetic diversity and evolutionary dynamics of Orthomarburgvirus marburgense species that includes both Marburg virus (MARV) Ravn (RAVV). Using sequence data from natural reservoir hosts human cases reported during outbreaks, conducted comprehensive analyses to explore variability, constructing haplotype networks at genome gene levels elucidate viral pathways. Our results revealed distinct trajectories for MARV RAVV, with exhibiting higher adaptability across different ecological regions. showed substantial evidence varied pressures, suggesting an ability adapt diverse environments. contrast, RAVV demonstrated limited diversity, no detected recombination events, stability. These differences indicate that, while continues diversify regions, may be constrained in its potential, possibly reflecting differing roles within ecology species. analysis explains mechanisms these viruses, highlighting is going through adaptation human-to-human transmission, alarmingly underscoring global concern about causing next pandemic. However, further transdisciplinary One Health research warranted answer some remaining questions including host range susceptibility domestic wildlife as well role biodiversity network disease’s dynamics.

Language: Английский

Citations

2