Recent Advances and Future Perspectives in Vascular Organoids and Vessel-on-Chip DOI Open Access

Gowtham Reddy Cheruku,

Chloe Veronica Wilson,

Suriya Raviendran

et al.

Published: July 14, 2024

Recent advancements in vascular organoid (VO) and vessel-on-chip (VoC) technologies have revolutionized our approach to studying cardiovascular diseases (CVDs), offering unprecedented insights through more physiologically relevant models. VOs generated from human pluripotent stem cells exhibit remarkable self-organization capabilities, forming complex three-dimensional structures that closely mimic blood vessel architecture function, while VoCs engineered with groundbreaking microfluidic systems meticulously recreate the physical functional attributes of vessels. These innovative constructs serve as powerful tools for investigating development, disease progression, therapeutic efficacy. By enabling creation patient-specific VoCs, they pave way personalized medicine approaches, allowing researchers delve into genetic variations, intricate cellular interactions, dynamic processes exceptional resolution. The synergy between cutting-edge such single-cell sequencing high-resolution imaging has further amplified their potential, unveiling novel mechanisms underlying CVDs identifying promising targets. Herein, we summarize different types present an extensive overview on generation applications CVDs. We will also highlight clinical translational challenges future perspectives around VoCs.

Language: Английский

Recent Advances and Future Perspectives in Vascular Organoids and Vessel-on-Chip DOI Open Access

Gowtham Reddy Cheruku,

Chloe Veronica Wilson,

Suriya Raviendran

et al.

Published: July 14, 2024

Recent advancements in vascular organoid (VO) and vessel-on-chip (VoC) technologies have revolutionized our approach to studying cardiovascular diseases (CVDs), offering unprecedented insights through more physiologically relevant models. VOs generated from human pluripotent stem cells exhibit remarkable self-organization capabilities, forming complex three-dimensional structures that closely mimic blood vessel architecture function, while VoCs engineered with groundbreaking microfluidic systems meticulously recreate the physical functional attributes of vessels. These innovative constructs serve as powerful tools for investigating development, disease progression, therapeutic efficacy. By enabling creation patient-specific VoCs, they pave way personalized medicine approaches, allowing researchers delve into genetic variations, intricate cellular interactions, dynamic processes exceptional resolution. The synergy between cutting-edge such single-cell sequencing high-resolution imaging has further amplified their potential, unveiling novel mechanisms underlying CVDs identifying promising targets. Herein, we summarize different types present an extensive overview on generation applications CVDs. We will also highlight clinical translational challenges future perspectives around VoCs.

Language: Английский

Citations

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