Arylpiperazine Derivatives and Cancer: A New Challenge in Medicinal Chemistry DOI Open Access

Giorgia Andreozzi,

Angela Corvino, Beatrice Severino

et al.

Published: July 19, 2024

In recent decades, there has been a startling rise in the number of cancer patients worldwide, which led to an amazing upsurge development novel anticancer treatment candidates. On positive note, arylpiperazines have garnered attention research due their potential as scaffolds for developing agents. These compounds exhibit diverse array biological activities, including cytotoxic effects against cells. Indeed, one key advantages aryl piperazines lies ability interact with various molecular targets implicated pathogenesis. Here, we focus on chemical structures several arylpiperazine derivatives, highlighting anti-proliferative activity different tumor cell lines. The modular structure, and combination therapies com-pounds make them valuable candidates further preclinical clinical investigations fight cancer. This review, providing careful analysis deriva-tives applications, allows researchers refine improve potency, selectivity, pharmacokinetic properties, thus advancing therapeutic oncology.

Language: Английский

From Infection to Tumor: Exploring the Therapeutic Potential of Ciprofloxacin Derivatives as Anticancer Agents DOI Creative Commons
Hesham M. Hassan,

Roket Hassan,

Ranya Mohammed Elmagzoub

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(1), P. 72 - 72

Published: Jan. 9, 2025

Ciprofloxacin, a widely used second-generation fluoroquinolone for treating bacterial infections, has recently shown notable anticancer properties. This review explores progress in developing ciprofloxacin derivatives with properties, emphasizing key structural changes that improve their therapeutic effectiveness by modifying the basic group at position 7, carboxylic acid 3, or both. It further investigates mechanisms which these fight cancer, such as inducing apoptosis, arresting cell cycle, inhibiting topoisomerase I and II, preventing tubulin polymerization, suppressing interleukin 6, blocking thymidine phosphorylase, multidrug resistance proteins, hindering angiogenesis. Additionally, it outlines future directions, enhancing efficacy, selectivity, investigating potential synergy other chemotherapeutic agents, offering promising avenue new therapies cancer.

Language: Английский

Citations

0
Arylpiperazine Derivatives and Cancer: A New Challenge in Medicinal Chemistry DOI Open Access

Giorgia Andreozzi,

Angela Corvino, Beatrice Severino

et al.

Published: July 19, 2024

In recent decades, there has been a startling rise in the number of cancer patients worldwide, which led to an amazing upsurge development novel anticancer treatment candidates. On positive note, arylpiperazines have garnered attention research due their potential as scaffolds for developing agents. These compounds exhibit diverse array biological activities, including cytotoxic effects against cells. Indeed, one key advantages aryl piperazines lies ability interact with various molecular targets implicated pathogenesis. Here, we focus on chemical structures several arylpiperazine derivatives, highlighting anti-proliferative activity different tumor cell lines. The modular structure, and combination therapies com-pounds make them valuable candidates further preclinical clinical investigations fight cancer. This review, providing careful analysis deriva-tives applications, allows researchers refine improve potency, selectivity, pharmacokinetic properties, thus advancing therapeutic oncology.

Language: Английский

Citations

2