Lassa Fever: Critical Review and Prospects for Control DOI Open Access

Marianne E. Besson,

Michel Pépin,

Pierre-Alexandre Metral

et al.

Published: July 22, 2024

Lassa Fever is a deadly viral haemorrhagic disease, causing annually several hundreds of deaths in the Gulf Guinea. This zoonotic disease primarily transmitted to humans by rodents genus Mastomys, while secondary interhuman transmission accounts for approximately 20% cases. Although this has been endemic rural zones years, it also characterised epidemic outbreaks dry season, responsible heavy death tolls. No licensed vaccine or satisfying treatment currently available. Disease management hindered incomplete knowledge epidemiology and distribution resulting from an inadequate health surveillance system. Additional scientific constraints such as genetic diversity virus lack understanding mechanisms immune protection complexify development vaccine. The intricate socio-economic context affected regions, monetary incentive drug development, allow persist some West Africa’s poorest communities. increase number reported cases fatality rate, expansion area, well threat represents internationally should urge global community work on control prevention. requires collaborative research medical countermeasures tailored public policies. Fever, created interconnection between animals, humans, ecosystems, embedded social context, be addressed with ‘One Health’ approach. article provides overview focusing Nigeria, discusses perspectives disease.

Language: Английский

Lassa Fever: Critical Review and Prospects for Control DOI Open Access

Marianne E. Besson,

Michel Pépin,

Pierre-Alexandre Metral

et al.

Published: July 22, 2024

Lassa Fever is a deadly viral haemorrhagic disease, causing annually several hundreds of deaths in the Gulf Guinea. This zoonotic disease primarily transmitted to humans by rodents genus Mastomys, while secondary interhuman transmission accounts for approximately 20% cases. Although this has been endemic rural zones years, it also characterised epidemic outbreaks dry season, responsible heavy death tolls. No licensed vaccine or satisfying treatment currently available. Disease management hindered incomplete knowledge epidemiology and distribution resulting from an inadequate health surveillance system. Additional scientific constraints such as genetic diversity virus lack understanding mechanisms immune protection complexify development vaccine. The intricate socio-economic context affected regions, monetary incentive drug development, allow persist some West Africa’s poorest communities. increase number reported cases fatality rate, expansion area, well threat represents internationally should urge global community work on control prevention. requires collaborative research medical countermeasures tailored public policies. Fever, created interconnection between animals, humans, ecosystems, embedded social context, be addressed with ‘One Health’ approach. article provides overview focusing Nigeria, discusses perspectives disease.

Language: Английский

Citations

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