Suppressive Effects of β-Hydroxybutyrate Administration on Lipopolysaccharide-Induced Inflammation in Broiler Chickens DOI Open Access

T Horiuchi,

Kyohei Furukawa, Motoi Kikusato

et al.

Published: July 24, 2024

β-hydroxybutyrate (BHB) is generated as one of the ketone bodies in liver under fasted and hypoglycemic conditions. While BHB utilized an alternative energy substrate extrahe-patic tissues/organs, this body has been reported to exert anti-inflammatory effects via modulating inflammatory signaling cascades. Several bacterial pathogens that originated hy-gienic litter conditions consecutively threaten chickens, its harmful constituent, lipopoly-saccharide (LPS), induces intestinal systemic inflammation. Therefore, management inflammation a significant concern poultry production. However, therapeutic on have yet be investigated chickens. This study demonstrated administration can alleviate LPS-induced broiler could dependent gene expression levels ketolytic enzymes, dehydrogenase-1 suc-cinyl-CoA:3-ketoacid CoA transferase, extrahepatic tissues/organs. first show possibly involvement utilization.

Language: Английский

Suppressive Effects of β-Hydroxybutyrate Administration on Lipopolysaccharide-Induced Inflammation in Broiler Chickens DOI Open Access

T Horiuchi,

Kyohei Furukawa, Motoi Kikusato

et al.

Published: July 24, 2024

β-hydroxybutyrate (BHB) is generated as one of the ketone bodies in liver under fasted and hypoglycemic conditions. While BHB utilized an alternative energy substrate extrahe-patic tissues/organs, this body has been reported to exert anti-inflammatory effects via modulating inflammatory signaling cascades. Several bacterial pathogens that originated hy-gienic litter conditions consecutively threaten chickens, its harmful constituent, lipopoly-saccharide (LPS), induces intestinal systemic inflammation. Therefore, management inflammation a significant concern poultry production. However, therapeutic on have yet be investigated chickens. This study demonstrated administration can alleviate LPS-induced broiler could dependent gene expression levels ketolytic enzymes, dehydrogenase-1 suc-cinyl-CoA:3-ketoacid CoA transferase, extrahepatic tissues/organs. first show possibly involvement utilization.

Language: Английский

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