Caveolae-Mediated Transcytosis and Its Role in Neurological Disorders

Biomolecules, Journal Year: 2025, Volume and Issue: 15(4), P. 456 - 456

Published: March 21, 2025

The blood–brain barrier (BBB) controls the flow of substances to maintain a homeostatic environment in brain, which is highly regulated and crucial for normal function central nervous system (CNS). Brain endothelial cells (bECs), are directly exposed blood, play most important role maintaining integrity BBB. Unlike other tissues, bECs have two unique features: specialized tight junctions actively suppressed transcellular vesicle trafficking (transcytosis). These features help relatively low permeability CNS barrier. In addition predominant BBB, caveolae-mediated adsorptive transcytosis has attracted much interest recent years. active suppression dynamically during development response diseases. Altered been reported several neurological diseases, but understanding this process limited. Here, we review based on previous studies discuss its breakdown BBB disorders.

Language: Английский

Ion Channel Regulation in Caveolae and Its Pathological Implications

Cells, Journal Year: 2025, Volume and Issue: 14(9), P. 631 - 631

Published: April 24, 2025

Caveolae are distinctive, flask-shaped structures within the cell membrane that play critical roles in cellular signal transduction, ion homeostasis, and mechanosensation. These composed of caveolin protein family enriched cholesterol sphingolipids, creating a unique lipid microdomain. contribute to functional regulation various channels through both physical interactions involvement complex signaling networks. Ion localized caveolae involved processes such as generation propagation action potentials, responses mechanical forces, metabolism. Dysregulation function has been linked development diseases, including cardiovascular disorders, neurodegenerative metabolic syndrome, cancer. This review summarizes channel caveolae, their pathological implications, offering new insights into potential therapeutic targets for channel-related diseases.

Language: Английский

Caveolae with GLP-1 and NMDA Receptors as Crossfire Points for the Innovative Treatment of Cognitive Dysfunction with Neurodegenerative Diseases

Published: July 24, 2024

Some of neurodegenerative diseases may be characterized by continuing behavioral and cognitive dysfunction that contains memory loss and/or apathy. Alzheimer's disease is the most typical type such deficit cognition alteration behavior. Despite huge efforts against disease, there has been yet no successful treatment for this disease. Interestingly, several possible risk genes to are frequently expressed within brain cells, which also linked cholesterol metabolism, lipid transport, exosomes caveolae formation, suggesting a therapeutic target consider dysfunctions. modulation autophagy/mitophagy with glucagon-like peptide-1 (GLP-1) N-methyl-d-aspartate (NMDA) receptors signaling offer novel approach prevent alleviate dysfunction. A paradigm both GLP-1 NMDA at sites promising crucial dysfunctions presented here, might able modify progression This research direction open potential move clinical care toward disease-modifying strategies maximal benefits patients without detrimental adverse events diseases.

Language: Английский