Analysis of the Effects of Epidural Anesthesia on the Nociception Level Index (NOL®) during Abdominal Surgery DOI Open Access
Alexander Ziebart,

David-Jonas Rothgerber,

Sophia Woldt

et al.

Published: July 26, 2024

Background: The NOL system (PMD-200™ Nociception Monitor; Medasense Ltd, Israel) is used for real-time detection of physiological nociception in anesthetized patients by assessing varia-bles indicative sympathetic activity, such as photoplethysmography, skin conductance, pe-ripheral temperature, and accelerometry, which are quantified into a "NOL" index. This index more sensitive than traditional clinical parameters estimating pain stress responses. While its effectiveness general anesthesia well-documented, efficacy epidural anes-thesia needs investigation. Methods: retrospective study analyzed dynamics compared to conventional pa-rameters after administration local anesthetic during abdominal surgeries. After Ethics Committee approval DRKS registration, 119 measurements were retrospectively following thoracic catheter administration. values assessed at 0, 1, 3, 5 minutes post-application heart rate, blood pressure, bispectral in-dex dynamics. Results: studys showed significant decrease post-local admin-istration, unlike classical parameters. Higher doses anesthetics led signifi-cant, dose-dependent Conclusions: the first demonstrate NOL-Index's nociceptive effects post-epidural administration, showing superiority over sensitivity dose variations.

Language: Английский

Analysis of the Effects of Epidural Anesthesia on the Nociception Level Index (NOL®) during Abdominal Surgery DOI Open Access
Alexander Ziebart,

David-Jonas Rothgerber,

Sophia Woldt

et al.

Published: July 26, 2024

Background: The NOL system (PMD-200™ Nociception Monitor; Medasense Ltd, Israel) is used for real-time detection of physiological nociception in anesthetized patients by assessing varia-bles indicative sympathetic activity, such as photoplethysmography, skin conductance, pe-ripheral temperature, and accelerometry, which are quantified into a "NOL" index. This index more sensitive than traditional clinical parameters estimating pain stress responses. While its effectiveness general anesthesia well-documented, efficacy epidural anes-thesia needs investigation. Methods: retrospective study analyzed dynamics compared to conventional pa-rameters after administration local anesthetic during abdominal surgeries. After Ethics Committee approval DRKS registration, 119 measurements were retrospectively following thoracic catheter administration. values assessed at 0, 1, 3, 5 minutes post-application heart rate, blood pressure, bispectral in-dex dynamics. Results: studys showed significant decrease post-local admin-istration, unlike classical parameters. Higher doses anesthetics led signifi-cant, dose-dependent Conclusions: the first demonstrate NOL-Index's nociceptive effects post-epidural administration, showing superiority over sensitivity dose variations.

Language: Английский

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