New Insights into Chronic Pancreatitis Treatment: Potential Mechanisms and Applications of Probiotics and Prebiotics DOI Open Access
Yingyu Pan, Jianing Li,

Zhengyang Fan

et al.

Published: Aug. 12, 2024

Chronic pancreatitis is a progressive fibroinflammatory disorder with no currently satisfactory treatment. Emerging evidence suggests an association between gut microbial dysbiosis and chronic pancreatitis. Although direct causative lacking, it hypothesized that the microbiota may play pivotal role in modulating pancreatic function via gut-pancreas axis. Thus, through administration of probiotics or prebiotics alleviate disorders. In this review, we first propose potential mechanisms by which specific ameliorate pancreatitis, including alleviation small intestinal bacterial overgrowth (SIBO), facilitation short-chain fatty acids (SCFAs) production, activation glucagon-like peptide 1 receptors (GLP-1Rs) pancreas. Since there are used for treatment have discussed research other disease models use to modulate endocrine exocrine functions prevent fibrosis. This provides indirect their application We anticipate will stimulate further investigation into axis therapeutic value

Language: Английский

New Insights into Chronic Pancreatitis Treatment: Potential Mechanisms and Applications of Probiotics and Prebiotics DOI Open Access
Yingyu Pan, Jianing Li,

Zhengyang Fan

et al.

Published: Aug. 12, 2024

Chronic pancreatitis is a progressive fibroinflammatory disorder with no currently satisfactory treatment. Emerging evidence suggests an association between gut microbial dysbiosis and chronic pancreatitis. Although direct causative lacking, it hypothesized that the microbiota may play pivotal role in modulating pancreatic function via gut-pancreas axis. Thus, through administration of probiotics or prebiotics alleviate disorders. In this review, we first propose potential mechanisms by which specific ameliorate pancreatitis, including alleviation small intestinal bacterial overgrowth (SIBO), facilitation short-chain fatty acids (SCFAs) production, activation glucagon-like peptide 1 receptors (GLP-1Rs) pancreas. Since there are used for treatment have discussed research other disease models use to modulate endocrine exocrine functions prevent fibrosis. This provides indirect their application We anticipate will stimulate further investigation into axis therapeutic value

Language: Английский

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