Identification of Antimicrobial Peptides from Nibribacter radioresistens, a UV and Gamma Radiation Tolerant Bacterium DOI Open Access
Sam Woong Kim, Woo Young Bang

Genes, Journal Year: 2025, Volume and Issue: 16(3), P. 353 - 353

Published: March 19, 2025

Background: Nibribacter radioresistens, a UV and gamma radiation-tolerant bacterium, was reported to have superior antibacterial activities against variety of pathogenic bacteria through the production antimicrobial peptides (AMPs), but nothing is known about its AMPs. Methods/Results: In this study, our genomic transcriptomic data showed that N. radioresistens genome contains 11 AMP gene candidates, designated as NB_AMP1 NB_AMP11, which are expressed differently in logarithmic growth stationary phase. Moreover, cell-free supernatant all Escherichia coli DH5α strains containing cloned AMPs except for NB_AMP5 NB_AMP7 exhibited both Gram-negative Gram-positive such E. Staphylococcus aureus. Synthetic supported AMPs, and, particular, synthetic NB_AMP2 S. Conclusions: Altogether, these results suggest candidates from may function peptides, effectively causing cellular lysis pore formation bacterial membrane.

Language: Английский

Antimicrobial Peptides, Their Production, and Potential in the Fight Against Antibiotic-Resistant Pathogens DOI Creative Commons
Margarita Saubenova, Alexander Rapoport, Zhanerke Yermekbay

et al.

Fermentation, Journal Year: 2025, Volume and Issue: 11(1), P. 36 - 36

Published: Jan. 17, 2025

The article reviews the literature on antimicrobial peptides (AMPs) that exhibit unique mechanisms, such as broad-spectrum activity, low development of resistance, and ability to modulate immune response host organism. Information is provided significant potential AMPs in fight against pathogens threatening human health food safety. Enrichment diet with biologically active obtained using proteolytic activity lactic acid bacteria (LAB) proposed a simple, accessible, viable alternative antibiotics does not have harmful side effect. review briefly covers methods for obtaining features LAB system responsible producing bioactive environment. It has been shown various strains makes it possible produce high-quality whey-based beverages different directions antagonistic opportunistic helps optimize gastrointestinal microbiota. assumed drinks can reduce dose antimicrobials combined therapy infectious diseases be preventive measure contagion spread resistance.

Language: Английский

Citations

1
Advancements in Antibacterial Therapy: Feature Papers DOI Creative Commons
Giancarlo Angeles Flores,

Gaia Cusumano,

Roberto Venanzoni

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(3), P. 557 - 557

Published: March 1, 2025

Antimicrobial resistance (AMR) is a growing global health crisis that threatens the efficacy of antibiotics and modern medical interventions. The emergence multidrug-resistant (MDR) pathogens, exacerbated by misuse in healthcare agriculture, underscores urgent need for innovative solutions. (1) Background: AMR arises from complex interactions between human, animal, environmental health, further aggravated overuse inadequate regulation antibiotics. Conventional treatments are increasingly ineffective, necessitating alternative strategies. Emerging approaches, including bacteriophage therapy, antimicrobial peptides (AMPs), nanotechnology, microbial extracellular vesicles (EVs), CRISPR-based antimicrobials, provide novel mechanisms complement traditional combating resistant pathogens. (2) Methods: This review critically analyzes advanced antibacterial strategies conjunction with systemic reforms such as stewardship programs, One Health framework, surveillance tools. These methods can enhance detection, guide interventions, promote sustainable practices. Additionally, economic, logistical, regulatory challenges impeding their implementation evaluated. (3) Results: technologies, CRISPR exhibit promising potential targeting mechanisms. However, disparities resource distribution barriers hinder widespread adoption. Public–private partnerships agriculture practices critical to overcoming these obstacles. (4) Conclusions: A holistic integrated approach essential mitigating impact AMR. By aligning therapeutic policies, fostering interdisciplinary collaboration, ensuring equitable distribution, we develop response this 21st-century challenge.

Language: Английский

Citations

1
Identification of Antimicrobial Peptides from Nibribacter radioresistens, a UV and Gamma Radiation Tolerant Bacterium DOI Open Access
Sam Woong Kim, Woo Young Bang

Genes, Journal Year: 2025, Volume and Issue: 16(3), P. 353 - 353

Published: March 19, 2025

Background: Nibribacter radioresistens, a UV and gamma radiation-tolerant bacterium, was reported to have superior antibacterial activities against variety of pathogenic bacteria through the production antimicrobial peptides (AMPs), but nothing is known about its AMPs. Methods/Results: In this study, our genomic transcriptomic data showed that N. radioresistens genome contains 11 AMP gene candidates, designated as NB_AMP1 NB_AMP11, which are expressed differently in logarithmic growth stationary phase. Moreover, cell-free supernatant all Escherichia coli DH5α strains containing cloned AMPs except for NB_AMP5 NB_AMP7 exhibited both Gram-negative Gram-positive such E. Staphylococcus aureus. Synthetic supported AMPs, and, particular, synthetic NB_AMP2 S. Conclusions: Altogether, these results suggest candidates from may function peptides, effectively causing cellular lysis pore formation bacterial membrane.

Language: Английский

Citations

0