Mass Spectrometry in Clinical Chemistry: Advancing Biomarker Discovery and Personalized Medicine DOI Open Access

Ahrum Son,

Woojin Kim, Jongham Park

et al.

Published: Aug. 12, 2024

Mass spectrometry (MS) has revolutionized clinical chemistry, offering unparalleled capabilities for biomolecule analysis. This review explores the growing significance of MS, particularly when coupled with liquid chromatography (LC-MS), in identifying disease biomarkers and quantifying biomolecules diagnostic prognostic purposes. The unique advantages MS accurately diverse molecules have positioned it as a cornerstone personalized medicine advancement. MS-based technologies transformed precision medicine, enabling comprehensive understanding mechanisms patient-specific treatment responses. LC-MS shown exceptional utility analyzing complex biological matrices, while high-resolution expanded analytical capabilities, allowing detection low-abundance elucidation pathways. integration other techniques, such ion mobility spectrometry, opened new avenues biomarker discovery validation. As we progress towards will be crucial addressing challenges individualized patient care, driving innovations diagnosis, prognosis, strategies.

Language: Английский

Mass Spectrometry in Clinical Chemistry: Advancing Biomarker Discovery and Personalized Medicine DOI Open Access

Ahrum Son,

Woojin Kim, Jongham Park

et al.

Published: Aug. 12, 2024

Mass spectrometry (MS) has revolutionized clinical chemistry, offering unparalleled capabilities for biomolecule analysis. This review explores the growing significance of MS, particularly when coupled with liquid chromatography (LC-MS), in identifying disease biomarkers and quantifying biomolecules diagnostic prognostic purposes. The unique advantages MS accurately diverse molecules have positioned it as a cornerstone personalized medicine advancement. MS-based technologies transformed precision medicine, enabling comprehensive understanding mechanisms patient-specific treatment responses. LC-MS shown exceptional utility analyzing complex biological matrices, while high-resolution expanded analytical capabilities, allowing detection low-abundance elucidation pathways. integration other techniques, such ion mobility spectrometry, opened new avenues biomarker discovery validation. As we progress towards will be crucial addressing challenges individualized patient care, driving innovations diagnosis, prognosis, strategies.

Language: Английский

Citations

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