Published: Aug. 20, 2024

Insect-specific viruses (ISVs) include that are restricted to the infection of mosquitoes and spread mostly through transovarial transmission. Despite using a distinct mode transmission, ISVs often closely related arthropod-borne (arboviruses) responsible for human diseases able infect both vertebrates. can also induce phenomenon called “superinfection exclusion”, whereby primary ISV in an insect inhibits subsequent viral infections insect. This has sparked interest use control pathogenic arboviruses transmitted by mosquitoes. In particular, insect-specific flaviviruses (ISF) have been shown inhibit vertebrate-infecting (VIFs) vitro vivo. potential as new ecologically friendly biological approach arboviral disease. For this intervention lasting impacts control, it is imperative ISFs maintained mosquito populations with high rates vertical Therefore, these strategies will need optimize transmission order establish persistently infected lines sustainable arbovirus control. review compares recent observations determinants understand how may be optimised effective

Language: Английский