Chemical Sensors and Biosensors Based on Metal–Organic Frameworks (MOFs)

Chemosensors, Journal Year: 2025, Volume and Issue: 13(2), P. 72 - 72

Published: Feb. 17, 2025

Metal–organic frameworks (MOFs), also referred to as porous coordination polymers [...]

Language: Английский

Doping Detection Based on the Nanoscale: Biosensing Mechanisms and Applications of Two-Dimensional Materials

Biosensors, Journal Year: 2025, Volume and Issue: 15(4), P. 227 - 227

Published: April 3, 2025

Doping undermines fairness in sports and threatens athlete health, while conventional detection methods like LC-MS GC-MS face challenges such as complex procedures, matrix interferences, lengthy processing times, limiting on-site applications. Two-dimensional (2D) materials, including graphene, MoS2, metal–organic frameworks (MOFs), offer promising solutions due to their large surface areas, tunable electronic structures, special interactions with doping agents, hydrogen bonding, π-π stacking, electrostatic forces. These materials enable signal transduction through changes conductivity or fluorescence quenching. This review highlights the use of 2D detection. For example, reduced graphene oxide–MOF composites show high sensitivity for detecting anabolic steroids testosterone, NiO/NGO nanocomposites exhibit strong selectivity stimulants ephedrine. However, environmental instability production costs hinder widespread application. Future efforts should focus on improving material stability chemical modifications, reducing costs, integrating these into advanced systems machine learning. Such advancements could revolutionize detection, ensuring protecting health.

Language: Английский

Paper-Based Analytical Devices Based on Amino-MOFs (Mil-125, UiO-66 and Mil-101) as Platforms towards Biosensing Applications

Published: Aug. 29, 2024

In this study, we have designed a promising platform based on metal-organic frameworks (MOFs) to develop paper-based analytical devices (PADs) immobilize biomolecules for application in biosensors. PADs become increasingly popular sensing applications recent years due their portability, low cost, simplicity, efficiency, fast detection capability, excellent sensitivity, and selectivity. addition, MOFs are an choice developing highly sensitive selective sensors. Their ability reversibly reproducibly adsorb desorb specific molecules allows using these materials as sensors various applications. They also offer the possibility modify structure properties, making them versatile adaptable different environments needs. research, synthesized characterized three amino-functionalized MOFs: UiO66-NH2 (Zr), MIL125-NH2 (Ti), MIL101-NH2 (Fe). These were used fabricate capable of portable monitoring alkaline phosphatase (ALP) enzyme activity by laser-induced fluorescence (LIF). Overall, amino-derivated MOF platforms demonstrate significant potential integration into biosensor PADs, offering key properties that enhance performance applicability chemistry diagnostics.

Language: Английский