Mitochondrial Dysfunction in Cardiac Disease: The Fort Fell DOI Open Access
Ioannis Paraskevaidis, Christos Kourek, Dimitrios Farmakis

et al.

Published: Oct. 12, 2024

Myocardial cells and extracellular matrix fulfil their goal thanks to the energetic availability. Indeed, mechanical electrical properties of heart are strongly depended on production-consumption equilibrium. The produced energy is used under several forms including kinetic, dynamic, thermal etc. Notably, as time goes by; aging well in case failure, although total remains almost constant contribution each form altered. Thermal increased, whereas dynamic kinetic decreased hence unable satisfy adequately cardiac work. Consequently, toxic products, unfolded /misfolded proteins, free radicals accumulated within myocardium. cell contraction – relaxation coupling, ion exchange, growth function failed, control apoptosis necrosis lacking micro macro-architecture change final result. Energy production consumption depends metabolic resources functional status silhouette cardiomyocytes non-cardiomyocytes - behavior. Mitochondria, intra-cellular organelles producing more than 95% ATP fulfill all above prerequisites being thus very important such we have better understand anatomy, homeostatic properties.

Language: Английский

Hypertrophic Cardiomyopathy Through the Lens of Mitochondria DOI Creative Commons
Tatiana V. Kirichenko, Ivan V. Zhivodernikov, Maria A. Kozlova

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 591 - 591

Published: Feb. 28, 2025

The mechanisms of pathogenesis hypertrophic cardiomyopathy are associated with mutations in the sarcomere genes cardiomyocytes and metabolic disorders cell, including mitochondrial dysfunction. Mitochondria characterized by presence their own DNA enzyme complexes involved oxidative reactions, which cause damage to protein structures membranes reactive oxygen species. Mitochondrial dysfunctions can also be encoding proteins lead a violation protective functions such as mitophagy, fusion, fission. Mutations myofibril negatively affect mitochondria through increased stress due an need for ATP. dysfunction is impaired ATP synthesis cardiac contractility, leading clinical manifestations cardiomyopathy. current review was designed characterize role based on published data; search publications analysis articles keywords “hypertrophic cardiomyopathy, mitochondria, dysfunction” PubMed Scopus databases up January 2025.

Language: Английский

Citations

0
Mitochondrial Dysfunction in Cardiac Disease: The Fort Fell DOI Open Access
Ioannis Paraskevaidis, Christos Kourek, Dimitrios Farmakis

et al.

Published: Oct. 12, 2024

Myocardial cells and extracellular matrix fulfil their goal thanks to the energetic availability. Indeed, mechanical electrical properties of heart are strongly depended on production-consumption equilibrium. The produced energy is used under several forms including kinetic, dynamic, thermal etc. Notably, as time goes by; aging well in case failure, although total remains almost constant contribution each form altered. Thermal increased, whereas dynamic kinetic decreased hence unable satisfy adequately cardiac work. Consequently, toxic products, unfolded /misfolded proteins, free radicals accumulated within myocardium. cell contraction – relaxation coupling, ion exchange, growth function failed, control apoptosis necrosis lacking micro macro-architecture change final result. Energy production consumption depends metabolic resources functional status silhouette cardiomyocytes non-cardiomyocytes - behavior. Mitochondria, intra-cellular organelles producing more than 95% ATP fulfill all above prerequisites being thus very important such we have better understand anatomy, homeostatic properties.

Language: Английский

Citations

2