Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
173, P. 116363 - 116363
Published: March 12, 2024
Ferroptosis,
a
novel
form
of
regulated
cell
death
characterized
by
dependence
on
iron
and
lipid
peroxidation,
has
been
implicated
in
wide
range
clinical
conditions
including
neurological
diseases,
cardiovascular
disorders,
acute
kidney
failure,
various
types
cancer.
Therefore,
it
is
critical
to
suppress
cancer
progression
proliferation.
Ferroptosis
can
be
triggered
cells
some
normal
synthetic
substances,
such
as
erastin,
Ras-selective
lethal
small
molecule-3,
or
pharmaceuticals.
Natural
bioactive
compounds
are
traditional
drug
discovery
tools,
have
therapeutically
used
dietary
additives
pharmaceutical
agents
against
malignancies.
The
fact
that
natural
products
multiple
targets
minimal
side
effects
led
notable
advances
anticancer
research.
Research
indicated
ferroptosis
also
induced
during
treatment.
In
this
review,
we
focused
the
most
recent
developments
emerging
molecular
processes
significance
To
provide
new
perspectives
future
development
ferroptosis-related
medications,
summary
implications
phytochemicals
triggering
through
ROS
production
ferritinophagy
induction
variety
Frontiers in Neuroscience,
Journal Year:
2023,
Volume and Issue:
17
Published: March 14, 2023
Spinal
cord
injury
is
a
serious
traumatic
disease.
As
Ferroptosis
has
been
increasingly
studied
in
recent
years,
it
found
to
be
closely
related
the
pathophysiological
processes
of
spinal
injury.
Iron
overload,
reactive
oxygen
species
accumulation,
lipid
peroxidation
and
glutamate
accumulation
associated
with
are
all
present
injury,
thus
thought
involved
pathological
secondary
This
article
highlights
relationship
between
lists
substances
that
improve
by
inhibiting
Ferroptosis,
concludes
discussion
problems
may
encountered
clinical
translation
inhibitors
as
means
enabling
their
faster
use
treatment.
Cells,
Journal Year:
2023,
Volume and Issue:
12(2), P. 311 - 311
Published: Jan. 13, 2023
Ferroptosis
is
a
type
of
iron-dependent
cell
death
caused
by
ferrous
iron
overload,
reactive
oxygen
species
generation
through
the
Fenton
reaction,
and
lipid
peroxidation,
leading
to
antioxidative
system
dysfunction
and,
ultimately,
membrane
damage.
The
functional
role
ferroptosis
in
human
physiology
pathology
considered
cause
or
consequence
diseases.
Circulating
exosomes
mediate
intercellular
communication
organ
crosstalk.
They
not
only
transport
proteins
nucleic
acids
derived
from
parental
cells
but
also
serve
as
vehicles
for
targeted
delivery
exogenous
cargo.
Exosomes
regulate
delivering
biological
material
recipient
cell,
affecting
ferroptosis-related
proteins,
transporting
ferritin-bound
out
cell.
This
review
discusses
pathogenesis
mediated
endogenous
therapeutic
potential
In
addition,
this
explores
exosome-mediated
diseases
with
an
emphasis
on
strategies
engineering
therapy.
Burns & Trauma,
Journal Year:
2024,
Volume and Issue:
12
Published: Jan. 1, 2024
Abstract
Traumatic
brain
injury
(TBI)
is
a
leading
cause
of
death
and
disability
worldwide,
with
~50
million
people
experiencing
TBI
each
year.
Ferroptosis,
form
regulated
cell
triggered
by
iron
ion-catalyzed
reactive
oxygen
species-induced
lipid
peroxidation,
has
been
identified
as
potential
contributor
to
traumatic
central
nervous
system
conditions,
suggesting
its
involvement
in
the
pathogenesis
TBI.
Alterations
metabolism
play
crucial
role
secondary
following
This
study
aimed
explore
ferroptosis
TBI,
focusing
on
disorders,
disorders
regulatory
axis
Xc−/glutathione/glutathione
peroxidase
4
Additionally,
we
examined
chronic
stage.
Based
these
findings,
discuss
therapeutic
interventions
targeting
after
In
conclusion,
this
review
provides
novel
insights
into
pathology
proposes
targets.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
173, P. 116363 - 116363
Published: March 12, 2024
Ferroptosis,
a
novel
form
of
regulated
cell
death
characterized
by
dependence
on
iron
and
lipid
peroxidation,
has
been
implicated
in
wide
range
clinical
conditions
including
neurological
diseases,
cardiovascular
disorders,
acute
kidney
failure,
various
types
cancer.
Therefore,
it
is
critical
to
suppress
cancer
progression
proliferation.
Ferroptosis
can
be
triggered
cells
some
normal
synthetic
substances,
such
as
erastin,
Ras-selective
lethal
small
molecule-3,
or
pharmaceuticals.
Natural
bioactive
compounds
are
traditional
drug
discovery
tools,
have
therapeutically
used
dietary
additives
pharmaceutical
agents
against
malignancies.
The
fact
that
natural
products
multiple
targets
minimal
side
effects
led
notable
advances
anticancer
research.
Research
indicated
ferroptosis
also
induced
during
treatment.
In
this
review,
we
focused
the
most
recent
developments
emerging
molecular
processes
significance
To
provide
new
perspectives
future
development
ferroptosis-related
medications,
summary
implications
phytochemicals
triggering
through
ROS
production
ferritinophagy
induction
variety
