Surgical treatment of thymic epithelial tumor and myasthenia gravis DOI Creative Commons
Gizem Işık, Akif Turna

Frontiers in Surgery, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 18, 2024

Thymic epithelial tumors originate from the cells of thymus and are typically diagnosed during 5th 6th decades life. The incidence is consistent between men women, averaging 1.7 cases per year. Thymomas, neuroendocrine tumors, thymic carcinomas subtypes with thymomas being most prevalent (75%–80%) following at 15%–20%. Thymoma carcinoma exhibit distinct disease courses; grow slowly confined to thymus, while demonstrate rapid growth metastasis. Overall survival rates vary, a 78% 5-year rate for thymoma 30% carcinoma. may be linked paraneoplastic autoimmune diseases, including myasthenia gravis, hypogammaglobulinemia, pure red cell aplasia, Cushing's syndrome, systemic lupus erythematosus, polymyositis. Staging can done according Masaoka-Koga and/or TNM 8th staging systems. treatment algorithm primarily determined by resectability, surgery (Extended Thymectomy) serving as foundational early-stage patients (TNM stage I-IIIA, I-III). Adjuvant radiotherapy or chemotherapy considered surgery. In advanced metastatic cases, first-line treatment, followed local control. Myasthenia an presents progressive muscle fatigue diplopia. Positive antibodies (Anti-AChR, Anti-MuSK, LRP4) electromyography aid in diagnosis, approximately 10% gravis also have thymoma. Treatment includes cholinesterase inhibitors immunotherapy agents, extended thymectomy effective surgical option drug-resistant cases. Minimally invasive approaches (video-assisted thoracoscopic robot-assisted surgery) demonstrated comparable oncological outcomes sternotomy, highlighting their effectiveness reliability.

Language: Английский

Thymus Surgery Prospectives and Perspectives in Myasthenia Gravis DOI Open Access

Paul Salahoru,

Cristina Grigorescu,

Marius Valeriu Hînganu

et al.

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(3), P. 241 - 241

Published: Feb. 23, 2024

The thymus is a lymphoid organ involved in the differentiation of T cells, and has central role physiopathogenesis Myasthenia Gravis (MG). This connection proved by series changes level neuromuscular junctions, which leads to decrease amplitude action potential post-synaptic membrane. Because this, presence anti-cholinergic receptor antibodies (AChR), characteristic MG, found, causes progressive regression effect acetylcholine at with appearance muscle weakness. thymectomy surgical variant drug therapy administered patients MG. In case nonthymomatous become therapeutic standard, despite fact that there no solid scientific evidence explain its positive effect. Videothoracoscopic surgery or robotic led length hospital stay for these patients. paper aims synthesize information presented literature order create background perspectives thymectomy.

Language: Английский

Citations

5
Outcomes after thymectomy in non-thymomatous myasthenia gravis DOI Open Access
Nathaniel Deboever, Xu Ying, Hope Feldman

et al.

Journal of Thoracic Disease, Journal Year: 2023, Volume and Issue: 15(6), P. 3048 - 3053

Published: May 9, 2023

Guidelines by the myasthenia gravis (MG) Foundation of America suggest patients aged 18 to 50 years with non-thymomatous (NTMG) benefit from thymectomy. Our objective was investigate utilization thymectomy in NTMG outside confines a clinical trial.From Optum de-identified Clinformatics Data Mart Claims Database (2007 2021), we identified diagnosed MG between 18-50 old. We then selected who received within 12 months diagnosis. Outcomes included use steroids, non-steroidal immunosuppressive agents (NSIS), and rescue therapy (plasmapheresis or intravenous immunoglobulin), as well NTMG-related emergency department (ED) visits hospital admissions. These outcomes were compared 6-months before after thymectomy.A total 1,298 met our inclusion criteria, whom 45 (3.47%) thymectomy, performed via minimally invasive surgery 53.3% cases (n=24). In comparing pre- post-operative period, noted that steroid increased (53.33% 66.67%, P=0.034), NSIS remained stable, decreased (44.44% 24.44%, P=0.007). Costs associated stable. However, mean costs (from $13,243.98 $8,486.26, P=0.035). Hospital admissions ED related There 2 readmissions 90 days (4.44%) thymectomy.Patients undergoing experienced less need for following resection, albeit rates prescriptions. Thymectomy is infrequently this patient population despite acceptable postsurgical outcomes.

Language: Английский

Citations

5
Measuring the Efficacy of Thymectomy for Pediatric Myasthenia Gravis Across Tertiary Children's Hospitals DOI
Christopher De Boer, Suhail Zeineddin, Katherine C. Ott

et al.

Pediatric Neurology, Journal Year: 2023, Volume and Issue: 148, P. 17 - 22

Published: Aug. 6, 2023

Language: Английский

Citations

4
Thymoma resection and myasthenia gravis: what is the neurological outcome in patients older than 65 years? DOI Creative Commons
Filippo Lococo, Carolina Sassorossi, Giulio Maurizi

et al.

Updates in Surgery, Journal Year: 2024, Volume and Issue: unknown

Published: July 9, 2024

Abstract To increase the neurological results in patients older than 65 years with myasthenia gravis after thymectomy, we retrospectively analysed this outcome a large bicentric cohort of (MG)years, for which surgery was indicated concurrent thymoma. From 1/2000 to 2/2022, 502 underwent thymectomy thymic epithelial tumours (TETs) two high-volume Institutions (167aged more years). Among them, 66 were affected by TET and MG, representing our final study group. The mean age MG onset 68.3 ± 6 years.At surgery, Osserman score 2 most diffuse (43, 65.1%), followed 1 (20, 30.3%). In 11 cases, diagnosis coincided thymoma diagnosis. other interval between 1.7 1.9. common surgical approach sternotomy (41,62.1%), RATS (14,21.2%). frequent TNM stage T1N0 (75.7%) had WHO type-B tumour. After radical 58 (88%) reported significant improvement. According MGFA-PIS, 4 (6%) complete stable remission, (16.7%) pharmacological 43 (65.2%) minimal manifestation, (3%) worsening/death 5 (7.6%) unchanged. No association found onset, kind therapy before (sternotomy vs others), tumour dimension, ITMIG preoperative score. For thymoma-afftected over years, seems be an effective treatment improve symptoms. We suggest set up clinical trials explore efficacy mini-invasive clinically selected aged years.

Language: Английский

Citations

0
Surgical treatment of thymic epithelial tumor and myasthenia gravis DOI Creative Commons
Gizem Işık, Akif Turna

Frontiers in Surgery, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 18, 2024

Thymic epithelial tumors originate from the cells of thymus and are typically diagnosed during 5th 6th decades life. The incidence is consistent between men women, averaging 1.7 cases per year. Thymomas, neuroendocrine tumors, thymic carcinomas subtypes with thymomas being most prevalent (75%–80%) following at 15%–20%. Thymoma carcinoma exhibit distinct disease courses; grow slowly confined to thymus, while demonstrate rapid growth metastasis. Overall survival rates vary, a 78% 5-year rate for thymoma 30% carcinoma. may be linked paraneoplastic autoimmune diseases, including myasthenia gravis, hypogammaglobulinemia, pure red cell aplasia, Cushing's syndrome, systemic lupus erythematosus, polymyositis. Staging can done according Masaoka-Koga and/or TNM 8th staging systems. treatment algorithm primarily determined by resectability, surgery (Extended Thymectomy) serving as foundational early-stage patients (TNM stage I-IIIA, I-III). Adjuvant radiotherapy or chemotherapy considered surgery. In advanced metastatic cases, first-line treatment, followed local control. Myasthenia an presents progressive muscle fatigue diplopia. Positive antibodies (Anti-AChR, Anti-MuSK, LRP4) electromyography aid in diagnosis, approximately 10% gravis also have thymoma. Treatment includes cholinesterase inhibitors immunotherapy agents, extended thymectomy effective surgical option drug-resistant cases. Minimally invasive approaches (video-assisted thoracoscopic robot-assisted surgery) demonstrated comparable oncological outcomes sternotomy, highlighting their effectiveness reliability.

Language: Английский

Citations

0