Glymphatic dysfunction evidenced by DTI-ALPS is related to obstructive sleep apnea intensity in newly diagnosed Parkinson’s disease DOI Creative Commons
Jiří Nepožitek, Stanislav Mareček,

Veronika Rottova

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 8, 2024

Abstract Glymphatic dysfunction can contribute to Parkinson’s disease (PD). Obstructive sleep apnea (OSA) disturbs sleep, which is necessary for its proper function, and frequent in PD. We investigated the glymphatic function de novo PD relation OSA. Fifty-four patients (mean age 58.9 ± 12.2 years) 32 controls 59.4 8.3 underwent polysomnography 3T magnetic resonance imaging of brain. Diffusion tensor along perivascular space (DTI-ALPS) was calculated using atlas-based automatic regions interest selection. In ALPS-index negatively correlated with apnea-hypopnea index (rho=-0.41; p = 0.002), oxygen desaturation (rho=-0.38; 0.006), stage N1 (rho=-0.42; arousal (rho=-0.24; 0.018), positively R (rho 0.32; 0.023), while no such correlations were observed. related OSA severity but not controls. imply that contributes neurodegeneration via impairment

Language: Английский

Widespread and Prolonged Pain May Reduce Brain Clearance Capacity Only via Sleep Impairment: Evidence from Participants with Knee Pain DOI
Pedro A. Valdés-Hernández, Soamy Montesino-Goicolea, Chavier Laffitte Nodarse

et al.

Journal of Pain, Journal Year: 2025, Volume and Issue: unknown, P. 105356 - 105356

Published: March 1, 2025

Language: Английский

Citations

1
Microstructure changes of the brain preceded glymphatic function changes in young obesity with and without food addiction DOI Creative Commons

Meizhi Yi,

Zeng Yule,

Song Wu

et al.

Meta-Radiology, Journal Year: 2025, Volume and Issue: unknown, P. 100137 - 100137

Published: March 1, 2025

Language: Английский

Citations

0
Glymphatic system dysfunction in cerebral infarction: advances and perspectives based on DTI-derived ALPS measures DOI
Bo Lin,

Y Y Leong,

Mazlyfarina Mohamad

et al.

American Journal of Translational Research, Journal Year: 2025, Volume and Issue: 17(3), P. 1630 - 1642

Published: Jan. 1, 2025

The glymphatic pathway plays a crucial role in the clearance of metabolic byproducts and solutes from cerebral tissue. Dysfunction has been associated with various neurological disorders, including ischemic stroke. Diffusion tensor imaging (DTI) derived Analysis aLong Perivascular Space (ALPS) have emerged as promising tools for evaluating function. This review aims to summarize current evidence on use DTI-derived ALPS measures assessing dysfunction stroke patients, explore their potential implications diagnosis, prognostication, treatment monitoring this patient population.

Language: Английский

Citations

0
Impairment of the intracranial lymphatic system in Parkinson's disease: a combined study of the meningeal lymphatics vessels and glymphatic system based on noninvasive neuroimaging DOI

Meng-Shun Huang,

Pan Zhang, Zhen Chen

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Abstract Background: The role of intracranial lymphatic circulation in Parkinson's disease (PD) causes more and concerns nowadays. The drainage function meningeal vessels (MLVs) the clearance capability glymphatic system have been demonstrated to associate with development PD. However, underlying mechanisms remain inadequately elucidated. Methods: 31 PD patients age- sex-matched healthy controls (HC) were recruited. group was divided into early (ePD) advanced (aPD) groups based on Hoehn-Yahr (H-Y) scale. tremor-dominant (tPD), myotonic-dominant (mPD), tremor-myotonic (t-mPD) subgroups according clinical symptoms. All subjects underwent specialized assessments noninvasive MRI examinations. volume MLVs diffusion tensor imaging analysis along perivascular space (DTI-ALPS) index calculated. differences correlations observed among volume, DTI-ALPS various parameters. Results：Both ePD aPD higher than HC (p＜0.001, p=0.019). For index, showed lower (p=0.001). And both (p＜0.001, p=0.022). Correlation revealed a negative association between H-Y scale (p=0.04), then ratio positively correlated age (p=0.01). Conclusion：The changes may elucidated dysfunction potential relationship warrants further in-depth investigation.

Language: Английский

Citations

0
The glymphatic system as a nexus between obesity and neurological diseases DOI
Bandy Chen, Stéphanie Lenck, Jean‐Léon Thomas

et al.

Nature Reviews Endocrinology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 20, 2024

Language: Английский

Citations

2
Rewiring of the glymphatic landscape in metabolic disorders DOI
Bandy Chen, David Meseguer, Stéphanie Lenck

et al.

Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

0
Glymphatic dysfunction evidenced by DTI-ALPS is related to obstructive sleep apnea intensity in newly diagnosed Parkinson’s disease DOI Creative Commons
Jiří Nepožitek, Stanislav Mareček,

Veronika Rottova

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 8, 2024

Abstract Glymphatic dysfunction can contribute to Parkinson’s disease (PD). Obstructive sleep apnea (OSA) disturbs sleep, which is necessary for its proper function, and frequent in PD. We investigated the glymphatic function de novo PD relation OSA. Fifty-four patients (mean age 58.9 ± 12.2 years) 32 controls 59.4 8.3 underwent polysomnography 3T magnetic resonance imaging of brain. Diffusion tensor along perivascular space (DTI-ALPS) was calculated using atlas-based automatic regions interest selection. In ALPS-index negatively correlated with apnea-hypopnea index (rho=-0.41; p = 0.002), oxygen desaturation (rho=-0.38; 0.006), stage N1 (rho=-0.42; arousal (rho=-0.24; 0.018), positively R (rho 0.32; 0.023), while no such correlations were observed. related OSA severity but not controls. imply that contributes neurodegeneration via impairment

Language: Английский

Citations

0