Unveiling the impact of circulating tumor cells: Two decades of discovery and clinical advancements in solid tumors
Critical Reviews in Oncology/Hematology,
Journal Year:
2024,
Volume and Issue:
203, P. 104483 - 104483
Published: Aug. 17, 2024
Language: Английский
Rare Cell Population Analysis in Early-Stage Breast Cancer Patients
Stefan Schreier,
No information about this author
Prapaphan Budchart,
No information about this author
Suparerk Borwornpinyo
No information about this author
et al.
Breast Cancer Basic and Clinical Research,
Journal Year:
2025,
Volume and Issue:
19
Published: Jan. 1, 2025
Background:
Circulating
rare
cells
participate
in
breast
cancer
evolution
as
systemic
components
of
the
disease
and
thus,
are
a
source
theranostic
information.
Exploration
cancer-associated
is
its
infancy.
Objectives:
We
aimed
to
investigate
classify
abnormalities
circulating
cell
population
among
early-stage
patients
using
fluorescence
marker
identification
cytomorphology.
In
addition,
we
sought
determine
dependency
these
markers
on
presence
tumors.
Design:
evaluated
validity
multi-rare-cell
detection
platform
demonstrated
utility
specific
subset
novel
approach
characterize
system.
Sampling
was
conducted
both
before
after
tumor
resection.
Methods:
Linearity
Rarmax
established
spike-in
approach.
The
includes
red
blood
lysis,
leukocyte
depletion
high-resolution
image
recording.
Rare
analysis
28
samples
(before
surgery)
from
14
with
cancer,
20
healthy
volunteers
9
noncancer
control
volunteers.
In-depth
cells,
including
endothelial-like
erythroblasts,
inflammation-associated
performed
phenotype
morphology-based
classification
Results:
linearly
over
range
5
950
spiked
an
average
recovery
84.6%.
epithelial
subsets
have
been
be
associated
or
independent
presence.
Furthermore,
certain
profile
patterns
may
treatment-related
adverse
effects.
sensitivity
detecting
tumor-presence
abnormality
surgery
43%
85.7%,
respectively,
specificity
100%
96.6%,
respectively.
Conclusion:
This
study
supports
idea
represent
entities
well
cancer.
latter
apparent
clinical
Language: Английский
Markers of inflammation as predictors of efficacy of trastuzumab therapy in HER2-positive metastatic breast cancer patients
Regulatory Mechanisms in Biosystems,
Journal Year:
2025,
Volume and Issue:
33(1), P. e25003 - e25003
Published: Jan. 4, 2025
Inflammatory
indexes
correlate
with
the
effectiveness
of
therapy
and
prognosis
many
cancer
types.
Our
study
aimed
to
identify
independent
predictors
efficacy
trastuzumab
affecting
progression-free
survival
(PFS)
overall
(OS)
in
patients
HER2-positive
metastatic
breast
(mBC).
The
retrospective
included
78
mBC
treated
at
Sumy
Regional
Clinical
Oncology
Center.
baseline
clin
i
copathological
characteristics
including
age,
number
metastases,
menopausal
status,
hormonal
trastuzumab-containing
regimen,
inflammatory
indexes,
such
as
neutrophil
lymphocyte
ratio
(NLR),
monocyte
(MLR),
platelet
(PLR)
pan-immune-inflammation
value
(PIV)
,
were
collected.
Cut-off
values
markers
determined
by
ROC
analysis.
AUC
≥0.7
was
considered
statistically
significant.
Factors
PFS
OS
using
multivariate
Cox
proportional
hazard
model.
Response
treatment
assessed
every
2-3
cycles.
Low
PLR
plus
chemotherapy
regimen
correlated
a
high
disease
control
rate.
Multivariate
analysis
prognostic
impact
st
tus,
on
patients.
Trast
u
zumab-containing
PFS.
Patients
who
received
chem
o
whose
before
low
had
significantly
better
For
OS,
showed
same
results.
OS.
is
associated
PFS,
may
be
an
effective
marker
for
identifying
cand
dates
most
benefit
from
trastuzumab.
Compared
monotherapy,
combination
correlates
longer
mBC.
Language: Английский
Diversity of the Circulating Tumor Markers: Perspectives of a Multimodal Liquid Biopsy
Biochemistry (Moscow),
Journal Year:
2024,
Volume and Issue:
89(11), P. 1985 - 1997
Published: Nov. 1, 2024
Language: Английский
Liquid biopsies and exosomal ncRNA: Transforming pancreatic cancer diagnostics and therapeutics
Ashok Kumar Balaraman,
No information about this author
Ehssan Moglad,
No information about this author
Muhammad Afzal
No information about this author
et al.
Clinica Chimica Acta,
Journal Year:
2024,
Volume and Issue:
unknown, P. 120105 - 120105
Published: Dec. 1, 2024
Language: Английский
Circulating tumor cells in solid malignancies: From advanced isolation technologies to biological understanding and clinical relevance in early diagnosis and prognosis
Divya Janjua,
No information about this author
Apoorva Chaudhary,
No information about this author
Udit Joshi
No information about this author
et al.
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer,
Journal Year:
2024,
Volume and Issue:
1880(1), P. 189236 - 189236
Published: Dec. 10, 2024
Language: Английский