Identification of Functional Immune Biomarkers in Breast Cancer Patients DOI Open Access

Roshanak Derakhshandeh,

Yuyi Zhu, Junxin Li

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12309 - 12309

Published: Nov. 16, 2024

Cancer immunotherapy has emerged as an effective, personalized treatment for certain patients, particularly those with hematological malignancies. However, its efficacy in breast cancer been marginal-perhaps due to cold, immune-excluded, or immune-desert tumors. Natural killer T (NKT) cells play a critical role immune surveillance and are reduced patients. Thus, we hypothesized that NKT could serve surrogate marker function. In order assess which patients would likely benefit from cell-based therapies, have developed quantitative method rapidly function using stimulation artificial antigen presenting followed by real-time PCR IFN-γ. We observed significant reduction the percentage of circulating compared healthy donors; however, majority had functional cells. When BC highly cells, indicated high IFN-γ induction, little no following there was difference cell number between groups, suggesting loss more impact than physical this subpopulation addition, assessed tumor-infiltrating lymphocytes PD-L1 expression within tumor microenvironment low responders. Further characterization gene signatures these groups identified concomitant decrease induction TNFα, LAG3, LIGHT next investigated mechanisms cancers suppress NKT-mediated anti-tumor responses. found secrete immunosuppressive lipids, commonly prescribed medications modulate lipid metabolism, can reduce growth restore

Language: Английский

Establishment and verification of a prognostic immune cell signature-based model for breast cancer overall survival DOI Open Access

Hailong Liu,

Hongguang Bao,

Jingying Zhao

et al.

Translational Cancer Research, Journal Year: 2024, Volume and Issue: 13(10), P. 5600 - 5615

Published: Oct. 1, 2024

Breast cancer (BRCA) is a prevalent and aggressive disease. Despite various treatments being applied, significant number of patients continue to experience unfavorable prognoses. Accurate prognosis prediction in BRCA crucial for tailoring individualized treatment plans improving patient outcomes. Recent studies have highlighted the significance immune cell infiltration tumor microenvironment (TME), but predicting survival remains challenging due heterogeneity BRCA. The aim this study was thus produce an signature-based framework capable with

Language: Английский

Citations

1
Identification of Functional Immune Biomarkers in Breast Cancer Patients DOI Open Access

Roshanak Derakhshandeh,

Yuyi Zhu, Junxin Li

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12309 - 12309

Published: Nov. 16, 2024

Cancer immunotherapy has emerged as an effective, personalized treatment for certain patients, particularly those with hematological malignancies. However, its efficacy in breast cancer been marginal-perhaps due to cold, immune-excluded, or immune-desert tumors. Natural killer T (NKT) cells play a critical role immune surveillance and are reduced patients. Thus, we hypothesized that NKT could serve surrogate marker function. In order assess which patients would likely benefit from cell-based therapies, have developed quantitative method rapidly function using stimulation artificial antigen presenting followed by real-time PCR IFN-γ. We observed significant reduction the percentage of circulating compared healthy donors; however, majority had functional cells. When BC highly cells, indicated high IFN-γ induction, little no following there was difference cell number between groups, suggesting loss more impact than physical this subpopulation addition, assessed tumor-infiltrating lymphocytes PD-L1 expression within tumor microenvironment low responders. Further characterization gene signatures these groups identified concomitant decrease induction TNFα, LAG3, LIGHT next investigated mechanisms cancers suppress NKT-mediated anti-tumor responses. found secrete immunosuppressive lipids, commonly prescribed medications modulate lipid metabolism, can reduce growth restore

Language: Английский

Citations

0