Weight Reduction with GLP-1 Agonists and Paths for Discontinuation While Maintaining Weight Loss

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 408 - 408

Published: March 13, 2025

Worldwide, nearly 40% of adults are overweight and 13% obese. Health consequences excess weight include cardiovascular diseases, type 2 diabetes, dyslipidemia, increased mortality. Treating obesity is challenging calorie restriction often leads to rebound gain. Treatments such as bariatric surgery create hesitancy among patients due their invasiveness. GLP-1 medications have revolutionized loss can reduce body in obese by between 15% 25% on average after about 1 year. Their mode action mimic the endogenous GLP-1, an intestinal hormone that regulates glucose metabolism satiety. However, drugs carry known risks and, since use for recent, may unforeseen well. They a boxed warning people with personal or family history medullary thyroid carcinoma multiple endocrine neoplasia syndrome 2. Gastrointestinal adverse events (nausea, vomiting, diarrhea) fairly common while pancreatitis obstruction rarer. There be lean mass well premature facial aging. A significant disadvantage using these high rate regain when they discontinued. Achieving success pharmacologic treatment then weaning avoid future negative effects would ideal.

Language: Английский

The Role of Perirenal Adipose Tissue in Carcinogenesis—From Molecular Mechanism to Therapeutic Perspectives

Cancers, Journal Year: 2025, Volume and Issue: 17(7), P. 1077 - 1077

Published: March 23, 2025

Perirenal adipose tissue (PRAT) exhibits particular morphological features, with its activity being mainly related to thermogenesis. However, an expanded PRAT area seems play a significant role in cardiovascular diseases, diabetes mellitus, and chronic kidney disease pathogenesis. Numerous studies have demonstrated that may support cancer progression invasion, obese patients. The mechanism underlying these processes is of dysregulation PRAT's secretion adipokines pro-inflammatory cytokines, such as leptin, adiponectin, chemerin, apelin, omentin-1, vistatin, nesfatin-1, other modulated by tumor cells. Cancer cells also induce metabolic reprogramming perirenal adipocytes, leading increased lipids lactate transfer the microenvironment, contributing growth hypoxic milieu. In addition, browning process has been specifically detected renal cell carcinoma (RCC), characterized upregulated expression brown/beige adipocytes markers (UCP1, PPAR-ɣ, c/EBPα, PGC1α) downregulated white fat markers, LEPTIN, SHOX2, HOXC8, HOXC9. Considering multifaceted cancer, modulation open new directions for oncologic therapy improvement. increasing evidence relationship between cells, our review aims provide comprehensive analysis adipocytes' impact on metastasis.

Language: Английский