Development and Validation of a Ferroptosis-Related Gene Signature for Overall Survival Prediction in Lung Adenocarcinoma DOI Creative Commons
Qi Tian, Yan Zhou, Lizhe Zhu

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2021, Volume and Issue: 9

Published: July 7, 2021

Background: Ferroptosis is an iron-dependent programmed cell death process. Recent studies have found that ferroptosis inducers hold promising potential in the treatment of lung adenocarcinoma (LUAD). However, comprehensive analysis about prognostic value ferroptosis-related genes LUAD remains to be elucidated. Methods: The RNA sequencing data and corresponding clinical information were obtained from Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases. A total 259 extracted FerrDb website. signature was developed by least absolute shrinkage selection operator (LASSO) Cox regression TCGA cohort, then validated 5 independent GEO cohorts. Ontology (GO), Kyoto Encyclopedia Genes Genomes (KEGG), gene set enrichment (GSEA) performed identify difference biological processes functions between different risk groups. expression levels core verified samples immunohistochemistry (IHC) erastin-treated lines real-time polymerase chain reaction (PCR). roles GPX2 DDIT4 as drivers line further confirmed vitro experiments. Results: 20 intersecting 70 DEGs 45 for LASSO analysis. 7 DEGs, stratified patients into two Kaplan-Meier showed overall survival (OS) high-risk group significantly worse than low-risk group. External validation cohorts ideal biomarker predicting patients. Significant fatty acid metabolism cycle-related pathways patterns adjacent normal tissues IHC, which almost consistent with results public database. Furthermore, changes related cycle after erastin also lines. In addition, silencing or could partially reverse erastin-induced ferroptosis. Conclusion: summary, based on indicated superior predictive performance Targeting holds a therapeutic alternative LUAD.

Language: Английский

Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research DOI Creative Commons

Xuhui Tong,

Rong Tang,

Mingming Xiao

et al.

Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)

Published: Dec. 8, 2022

Abstract Many types of human cells self-destruct to maintain biological homeostasis and defend the body against pathogenic substances. This process, called regulated cell death (RCD), is important for various activities, including clearance aberrant cells. Thus, RCD pathways represented by apoptosis have increased in importance as a target development cancer medications recent years. However, because tumor show avoidance apoptosis, which causes treatment resistance recurrence, numerous studies been devoted alternative mortality processes, namely necroptosis, pyroptosis, ferroptosis, cuproptosis; these modalities extensively studied shown be crucial therapy effectiveness. Furthermore, evidence suggests that undergoing may alter immunogenicity microenvironment (TME) some extent, rendering it more suitable inhibiting progression metastasis. In addition, other components TME undergo abovementioned forms induce immune attacks on cells, resulting enhanced antitumor responses. Hence, this review discusses molecular processes features cuproptosis effects novel proliferation Importantly, introduces complex affect biology. It also summarizes potential agents nanoparticles or inhibit their therapeutic based from vivo vitro reports clinical trials inducers evaluated treatments patients. Lastly, we summarized impact modulating drug advantages adding modulators over conventional treatments.

Language: Английский

Citations

500
Overcoming cancer chemotherapy resistance by the induction of ferroptosis DOI
Yumin Wang,

Xiaorui Wu,

Ren Zhao

et al.

Drug Resistance Updates, Journal Year: 2022, Volume and Issue: 66, P. 100916 - 100916

Published: Dec. 29, 2022

Language: Английский

Citations

168
Mechanisms of cancer cell death induction by paclitaxel: an updated review DOI
Shuang Zhao, Yufei Tang, Ruohan Wang

et al.

APOPTOSIS, Journal Year: 2022, Volume and Issue: 27(9-10), P. 647 - 667

Published: July 18, 2022

Language: Английский

Citations

114
Induction and application of ferroptosis in cancer therapy DOI Creative Commons
Qing Nie, Yue Hu, Xiao Yu

et al.

Cancer Cell International, Journal Year: 2022, Volume and Issue: 22(1)

Published: Jan. 7, 2022

At present, more than one cell death pathways have been found, of which is ferroptosis. Ferroptosis was discovered in 2012 and described as an iron-dependent lipid peroxidation-driven regulated pathway. In the past few years, ferroptosis has shown to induce tumor death, providing new ideas for treatment. this article, we summarize latest advances ferroptosis-induced therapy at intersection biology, molecular redox materials chemistry. First, state characteristics cells, then introduce key mechanism ferroptosis, describes relationship between oxidative stress signaling pathways. Finally, focused on several types inducers by scholars, application systemic chemotherapy, radiotherapy, immunotherapy nanomedicine, hope that can exert its potential treatment tumors.

Language: Английский

Citations

92
CircPIAS1 promotes hepatocellular carcinoma progression by inhibiting ferroptosis via the miR-455-3p/NUPR1/FTH1 axis DOI Creative Commons
Xiaoyu Zhang, Shanshan Li, Yurong Gu

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: May 28, 2024

Abstract Background The role of circRNAs in hepatocellular carcinoma (HCC) progression remains unclear. CircPIAS1 (circBase ID: hsa_circ_0007088) was identified as overexpressed HCC cases through bioinformatics analysis. This study aimed to investigate the oncogenic properties and mechanisms circPIAS1 development. Methods Functional analyses were conducted assess circPIAS1’s impact on cell proliferation, migration, ferroptosis. Xenograft mouse models employed evaluate effects tumor growth pulmonary metastasis vivo. Bioinformatics analysis, RNA immunoprecipitation, luciferase reporter assays utilized elucidate molecular pathways influenced by circPIAS1. Additional techniques, including pulldown, fluorescence situ hybridization (FISH), chromatin immunoprecipitation (ChIP), qPCR, western blotting, used further explore underlying mechanisms. Results expression elevated tissues cells. Silencing suppressed proliferation migration both vitro Mechanically, overexpression inhibited ferroptosis competitively binding miR-455-3p, leading upregulation Nuclear Protein 1 (NUPR1). Furthermore, NUPR1 promoted FTH1 transcription, enhancing iron storage cells conferring resistance Treatment with ZZW-115, an inhibitor, reversed tumor-promoting sensitized lenvatinib. Conclusion highlights critical modulation Targeting circPIAS1/miR-455-3p/NUPR1/FTH1 regulatory axis may represent a promising therapeutic strategy for HCC.

Language: Английский

Citations

32
Dual Role of Reactive Oxygen Species and their Application in Cancer Therapy DOI Creative Commons

Run Huang,

Huan Chen,

Jiayu Liang

et al.

Journal of Cancer, Journal Year: 2021, Volume and Issue: 12(18), P. 5543 - 5561

Published: Jan. 1, 2021

Reactive oxygen species (ROS) play a dual role in the initiation, development, suppression, and treatment of cancer.Excess ROS can induce nuclear DNA, leading to cancer initiation.Not only that, but also inhibit T cells natural killer promote recruitment M2 polarization macrophages; consequently, escape immune surveillance defense.Furthermore, tumor invasion metastasis by triggering epithelial-mesenchymal transition cells.Interestingly, massive accumulation inhibits growth two ways: (1) blocking cell proliferation suppressing signaling pathway, cycle, biosynthesis nucleotides ATP (2) inducing death via activating endoplasmic reticulum stress-, mitochondrial-, P53-apoptotic pathways ferroptosis pathway.Unfortunately, adapt self-adaption system.This review highlighted bidirectional regulation cancer.The study further discussed application massively accumulated treatment.Of note, self-adaptive ability should be taken into consideration for prevention.

Language: Английский

Citations

103
Artemisinin Derivatives Inhibit Non-small Cell Lung Cancer Cells Through Induction of ROS-dependent Apoptosis/Ferroptosis DOI Creative Commons
Qiuting Zhang,

Huimei Yi,

Hui Yao

et al.

Journal of Cancer, Journal Year: 2021, Volume and Issue: 12(13), P. 4075 - 4085

Published: Jan. 1, 2021

Non-small cell lung cancer (NSCLC) is one of the major cancer-related causes morbidity and mortality worldwide.Despite progress in treatment, there still an urgent need to discover novel therapeutic agents for NSCLC.Natural products represent a rich source bioactive compounds.Through natural compound library screening assay, we found that group anti-insect drugs had significant inhibitory effect on proliferation NSCLC cells.Among drugs, two derivatives artemisinin, i.e., artesunate (ART) dihydroartemisinin (DHA), well-known anti-malarial have been shown possess selective anti-cancer properties.Mechanistically, ART DHA induced apoptosis A549 cells as evidenced by decreased protein level VDAC increased caspase 3 cleavage.Furthermore, cystine/glutamate transporter (xCT), core negative regulator ferroptosis, was downregulated DHA.The mRNA transferrin receptor (TFRC), positive upregulated DHA.ART/DHA-induced ferroptosis were partly reversed N-Acetyl-L-cysteine (NAC), ROS scavenger, ferrostatin-1, inhibitor, respectively.These results suggest artemisinin anti-NSCLC activity through induction ROS-dependent apoptosis/ferroptosis.Our findings provide experimental basis potential application class NSCLC.

Language: Английский

Citations

97
SLC7A11/ xCT is a target of miR-5096 and its restoration partially rescues miR-5096-mediated ferroptosis and anti-tumor effects in human breast cancer cells DOI
Poonam Yadav, Priyanshu Sharma, Sandhya Sundaram

et al.

Cancer Letters, Journal Year: 2021, Volume and Issue: 522, P. 211 - 224

Published: Sept. 24, 2021

Language: Английский

Citations

90
Crosstalk between ferroptosis and the epithelial-mesenchymal transition: Implications for inflammation and cancer therapy DOI

Nasim Ebrahimi,

Samaneh Adelian,

Siavash Shakerian

et al.

Cytokine & Growth Factor Reviews, Journal Year: 2022, Volume and Issue: 64, P. 33 - 45

Published: Jan. 21, 2022

Language: Английский

Citations

69
Ferroptosis and Its Role in Chronic Diseases DOI Creative Commons
Wenli Hu, Kehong Liang, Hong Zhu

et al.

Cells, Journal Year: 2022, Volume and Issue: 11(13), P. 2040 - 2040

Published: June 27, 2022

Ferroptosis, which has been widely associated with many diseases, is an iron-dependent regulated cell death characterized by intracellular lipid peroxide accumulation. It exhibits morphological, biochemical, and genetic characteristics that are unique in comparison to other types of death. The course ferroptosis can be accurately the metabolism iron, lipids, amino acids, various signal pathways. In this review, we summarize basic ferroptosis, its regulation, as well relationship between chronic diseases such cancer, nervous system metabolic inflammatory bowel diseases. Finally, describe regulatory effects food-borne active ingredients on ferroptosis.

Language: Английский

Citations

65