Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)
Published: Sept. 12, 2024
Ribosomal RNA Processing 8 (RRP8) is a gene associated with modification and has been implicated in the development of several types tumors recent research. Nevertheless, biological importance RRP8 pan-cancer not yet thoroughly comprehensively investigated.
Language: Английский
Burns & Trauma, Journal Year: 2025, Volume and Issue: 13
Published: Jan. 1, 2025
The circadian clock is an internal timekeeper system that regulates biological processes through a central and peripheral clocks controlling various genes. Basic helix-loop-helix ARNT-like 1 (BMAL1), also known as aryl hydrocarbon receptor nuclear translocator-like protein (ARNTL1), key component of the clock. deletion BMAL1 alone can abolish rhythms human body. plays critical role in immune cell function. Dysregulation linked to immune-related diseases such autoimmune diseases, infectious cancer, vice versa. This review highlights significant governing cells, including their development, differentiation, migration, homing, metabolism, effector functions. study explores how dysregulation have far-reaching implications potentially contribute onset sepsis, trauma. Furthermore, this discusses treatments for target disorders. Understanding impact on function provide insights into pathogenesis help development more effective treatment strategies. Targeting has been demonstrated achieve good efficacy indicating its promising potential targetable therapeutic these diseases.
Language: Английский
Citations
4
Research, Journal Year: 2025, Volume and Issue: 8
Published: Jan. 1, 2025
The intricate relationship between cancer, circadian rhythms, and aging is increasingly recognized as a critical factor in understanding the mechanisms underlying tumorigenesis cancer progression. Aging well-established primary risk for while disruptions rhythms are intricately associated with progression of various tumors. Moreover, itself disrupts leading to physiological changes that may accelerate development. Despite these connections, specific interplay processes their collective impact on remains inadequately explored literature. In this review, we systematically explore influence We discuss how core genes tumor prognosis, highlighting shared hallmarks such genomic instability, cellular senescence, chronic inflammation. Furthermore, examine aging, focusing crosstalk contributes tumorigenesis, proliferation, apoptosis, well metabolism stability. By elucidating common pathways linking review provides new insights into pathophysiology identifies potential therapeutic strategies. propose targeting regulation could pave way novel treatments, including chronotherapy antiaging interventions, which offer important benefits clinical management cancer.
Language: Английский
Citations
2
International Journal of Cancer, Journal Year: 2025, Volume and Issue: unknown
Published: April 23, 2025
Abstract Single‐cell analysis is a transformative approach to understanding cellular heterogeneity in aging and cancer, interconnected processes driven by mechanisms like senescence immune modulation. This review explores how influences cancer initiation, progression, treatment resistance within the tumor microenvironment (TME). By examining recent studies using single‐cell technologies, we reveal nuanced roles of tumorigenesis, interactions, therapeutic outcomes. Aging closely tied with senescent cells demonstrating heightened proliferative, invasive, metastatic capabilities. Emerging senolytic therapies targeting aging‐related pathways hold promise for enhancing efficacy. Advanced tools such as spatial transcriptomics, molecular probes, artificial intelligence further refine our TME. integrating these future research can clarify intricate interactions between advancing precision oncology improving outcomes patients.
Language: Английский
Citations
0
Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12
Published: Nov. 13, 2024
Background and Aims Diabetic foot ulcers (DFUs) are a serious complication of diabetes mellitus (DM), affecting around 25% individuals with DM. Primary treatment DFU involves wound off-loading, surgical debridement, dressings to provide moist environment, vascular assessment, appropriate antibiotics through multidisciplinary approach. Three-dimensional (3D) printing technology is considered an innovative tool for the management DFUs. The utilization 3D in modernization traditional methods exploration new techniques. This review discusses recent advancements application care, development personalized interventions Methods We searched electronic database years 2019–2024. Studies related use were included. Results A total 25 identified articles based on search citation network analysis. After removing duplicates, 18 remained, three that did not meet inclusion criteria removed after reading title/abstract. 97 relevant included during references. In total, 112 Conclusion offers unparalleled advantages, particularly realm treatment. amalgamation has yielded favorable outcomes decelerating progression DFUs facilitating healing. However, there limited body research regarding domain
Language: Английский
Citations
1
Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)
Published: Sept. 12, 2024
Ribosomal RNA Processing 8 (RRP8) is a gene associated with modification and has been implicated in the development of several types tumors recent research. Nevertheless, biological importance RRP8 pan-cancer not yet thoroughly comprehensively investigated.
Language: Английский
Citations
0