FLASH Radiotherapy: Technical Advances, Evidence of the FLASH Effect and Mechanistic Insights DOI
Mustapha Chaoui, O. Bouhali,

Yahya Tayalati

et al.

Biomedical Physics & Engineering Express, Journal Year: 2025, Volume and Issue: 11(2), P. 022003 - 022003

Published: March 5, 2025

Cancer is one of the leading causes death worldwide, responsible for nearly 10 million deaths in 2020, with approximately 50% patients receiving radiation therapy as part their treatment (Baskar et al 2012). Preclinical investigations studies have shown that FLASH radiotherapy (FLASH-RT), delivering ultra-high dose rates (UHDR), preserves healthy tissue integrity and reduces toxicity, all while maintaining an effective tumor response compared to conventional (CONV-RT), combined biological benefit was termed effect. This article comprehensively surveys pertinent research conducted within FLASH-RT, explores facilities used this realm, delves into hypothesized mechanism perspectives, addresses challenges trigger In addition, we discuss potential prospects FLASH-RT examine obstacles require resolution before its clinical implementation can become a reality.

Language: Английский

FLASH Radiotherapy: Technical Advances, Evidence of the FLASH Effect and Mechanistic Insights DOI
Mustapha Chaoui, O. Bouhali,

Yahya Tayalati

et al.

Biomedical Physics & Engineering Express, Journal Year: 2025, Volume and Issue: 11(2), P. 022003 - 022003

Published: March 5, 2025

Cancer is one of the leading causes death worldwide, responsible for nearly 10 million deaths in 2020, with approximately 50% patients receiving radiation therapy as part their treatment (Baskar et al 2012). Preclinical investigations studies have shown that FLASH radiotherapy (FLASH-RT), delivering ultra-high dose rates (UHDR), preserves healthy tissue integrity and reduces toxicity, all while maintaining an effective tumor response compared to conventional (CONV-RT), combined biological benefit was termed effect. This article comprehensively surveys pertinent research conducted within FLASH-RT, explores facilities used this realm, delves into hypothesized mechanism perspectives, addresses challenges trigger In addition, we discuss potential prospects FLASH-RT examine obstacles require resolution before its clinical implementation can become a reality.

Language: Английский

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