Enantioselective Nickel‐Catalyzed C(sp³)−H Activation of Formamides

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(42)

Published: Aug. 29, 2022

Enantioselective Ni-catalyzed C(sp3 )-H bond activation remains an elusive challenge. Herein, we used phosphine oxide-ligated Ni-Al bimetallic catalyst to realize enantioselective aliphatic of formamides, providing a series chiral N-containing heterocycles in 40-95 % yield and 70-95 ee.

Language: Английский

Enantioselective Nickel‐Catalyzed C(sp³)−H Activation of Formamides

Angewandte Chemie, Journal Year: 2022, Volume and Issue: 134(42)

Published: Aug. 29, 2022

Abstract Enantioselective Ni‐catalyzed C(sp 3 )−H bond activation remains an elusive challenge. Herein, we used phosphine oxide‐ligated Ni−Al bimetallic catalyst to realize enantioselective aliphatic of formamides, providing a series chiral N‐containing heterocycles in 40–95 % yield and 70–95 ee.

Language: Английский