Bidirectional relationships between pain and patterns of cannabis and tobacco use in a US nationally representative sample
Pain,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 21, 2024
Abstract
One-fifth
of
US
adults
experience
chronic
pain,
which
is
associated
with
increased
tobacco
and
cannabis
use.
Although
bidirectional
relationships
between
pain
have
been
demonstrated,
pathways
use,
co-use
are
understudied.
We
aimed
to
estimate
the
effects
(1)
substance
use
(exclusive
tobacco)
on
later
intensity,
(2)
intensity
Data
were
from
31,983
in
biennial
surveys
(2015-2021)
nationally
representative
longitudinal
Population
Assessment
Tobacco
Health
Study
(n
=
71,055
pairs
consecutive
surveys;
T1
T2).
Past-week
was
dichotomized
(≤4/10
no/low
pain;
>4/10
moderate/severe
pain).
Mutually
exclusive
categories
(past
30
days)
no
cannabis/tobacco
use;
co-use.
Logistic
regression
assessed
whether
affected
at
T2.
Multinomial
models
status
Compared
T1,
(OR:
2.29
[95%
CI:
2.09-2.51]),
(2.00
[1.86-2.14]),
(1.35
[1.13-1.61])
all
Moderate/severe
odds
(2.43
[2.22-2.66]),
(2.12
[1.98-2.28]),
(1.46
[1.29-1.65])
compared
T2,
T2
Findings
demonstrated
indicate
potential
synergy
respect
pain.
Language: Английский
Genetically Regulated Gene Expression in the Brain Associated With Chronic Pain: Relationships With Clinical Traits and Potential for Drug Repurposing
Biological Psychiatry,
Journal Year:
2023,
Volume and Issue:
95(8), P. 745 - 761
Published: Sept. 9, 2023
Chronic
pain
is
a
common,
poorly
understood
condition.
Genetic
studies
including
genome-wide
association
have
identified
many
relevant
variants,
which
yet
to
be
translated
into
full
understanding
of
chronic
pain.
Transcriptome-wide
using
transcriptomic
imputation
methods
such
as
S-PrediXcan
can
help
bridge
this
genotype-phenotype
gap.
Language: Английский
Repurposing Antihypertensive and Statin Medications for Spinal Pain
Spine,
Journal Year:
2023,
Volume and Issue:
48(22), P. 1568 - 1574
Published: Aug. 4, 2023
Mendelian
randomization
(MR)
study.To
examine
whether
antihypertensive
medications
(beta-blockers,
calcium
channel
blockers,
and
angiotensin-converting
enzyme
inhibitors)
statins
can
be
repurposed
to
prevent
or
treat
spinal
pain
(back
neck
pain).Observational
studies
a
recent
MR
study
have
found
associations
between
elevated
blood
pressure
greater
risk
of
back
pain.
Observational
hyperlipidemia
statin
use
No
prior
examined
the
effects
antihypertensives
on
pain.This
was
two-sample
using
publicly
available
summary
statistics
from
large-scale
genome-wide
association
(GWAS).
Sample
sizes
in
exposure
GWASs
were
n=757,601
(systolic
pressure)
n=173,082
(low-density
lipoprotein
cholesterol),
n=1,028,947
for
outcome
GWAS
defined
as
health
care
seeking
any
pain-related
diagnosis.
Genes
cis-acting
variants
identified
proxies
drug
targets
interest.
analyses
used
inverse-variance
weighted
meta-analysis.
The
threshold
statistical
significance
after
correction
multiple
testing
P
<0.0125.No
statistically
significant
these
with
found.
However,
findings
suggestive
protective
effect
beta-blockers
(odds
ratio
[OR]
0.84,
95%
confidence
interval
[CI]
0.72-0.98;
=0.03),
blockers
(OR
1.12,
CI
1.02-1.24;
=0.02).A
suggested
current
study,
consistent
observational
various
other
phenotypes.
detrimental
must
interpreted
context
conflicting
directions
nonspinal
phenotypes
studies.This
spinal.This
ranging
size
173,082
1,028,947
adults.While
no
found,
0.72
0.98;
p=
0.03),
1.02
1.24;
0.02).
Language: Английский