Published: Feb. 13, 2024
Many metabolic processes at the molecular level support both viral attack strategies and human defenses during Covid-19. This knowledge is of vital importance in design antiviral drugs. In this study, we extracted 18 articles (2021-2023) from PubMed reporting discovery hub-nodes specific for liver covid-19, identifying 142 hub-nodes. They are highly connected proteins which to get deep functional information on when used as seeds. Therefore, evaluated structural significance each them endorse their reliable use After filtering, remaining 111 hubs were by STRING an enriched interactome 1111 nodes (13,494 interactions). It shows strategy entire cytoplasmic translational system, including ribosomes, take control protein bio-synthesis. We SARS2-Human-Proteome Interaction Database (33,791 interactions), de-signed us with BioGRID data implement a reverse-engineering process that identified actively interacting proteins. The results show 57% di-rectly involved Covid, strong impairment ribosome spliceosome, defense mechanism against cellular stress p53 and, surprisingly, capacity multiple attacks single reveal underlying evolutionary-topological mechanisms. Viral behavior over time suggests different organs.
Language: Английский