Mathematical Analysis of Stem Cell Dynamics in Acute Myeloid Leukemia: Towards Precision Medicine Strategies

International Journal of Science and Research (IJSR), Journal Year: 2024, Volume and Issue: 13(5), P. 528 - 535

Published: May 5, 2024

This paper provided a thorough examination of the dynamics hematopoietic stem cells and leukemic in acute myeloid leukemia through mathematical modeling. AML, heterogeneous hematologic malignancy characterized by abnormal cell proliferation bone marrow, presents significant challenges understanding disease progression treatment response. The study reviews various modeling techniques, including agent-based modeling, ordinary differential equations, stochastic models, to analyze complex interactions between cells, their progeny, marrow microenvironment. Recent advances experimental methodologies for measuring key parameters integrating these data into models are also highlighted. Furthermore, discussed potential guide development personalized therapeutic strategies AML patients. It aims unravel growth HSCs LSCs within considering them as network interconnected compartments representing distinct stages cellular differentiation. introduced an innovative fractional order derivative-based framework, which re-examined reformulated classical better capture intricate interplay self-renewal rates across diverse sub-stages By shedding light on regulatory mechanisms governing dynamics, this approach provides valuable insights pathophysiology disorders, particularly leukemia.

Language: Английский

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Exploring capillary-tissue fluid exchange: Insights into red cell deformation in narrow vessels and its clinical implications

International Journal of Fauna and Biological Studies, Journal Year: 2024, Volume and Issue: 11(3), P. 08 - 14

Published: Jan. 1, 2024

This work focuses on how blood move between tiny vessels (capillaries) and surrounding tissues, especially when the capillary diameter is smaller than that of red cells (RBCs). It has shown in such narrow vessels, there very little space RBC vessel wall, allowing plasma to squeeze through. this at different factors like shape deformed RBCs, their speed, easily tissues allow fluids pass (permeability) affect flow blood. also are less permeable, smoother. Also, faster-moving RBCs encounter resistance. By comparing its findings with other models, study demonstrates value understanding dynamics small vessels. knowledge could lead development new diagnostic tools for various diseases.

Language: Английский

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Exploring Shilajatu's Therapeutic Potential in Diabetes Management: A Comprehensive Study Integrating Ayurvedic Wisdom and Modern Science

International Journal of Science and Research (IJSR), Journal Year: 2024, Volume and Issue: 13(5), P. 1374 - 1380

Published: May 5, 2024

Diabetes mellitus poses a significant global health challenge characterized by elevated blood glucose levels, necessitating effective management strategies to mitigate complications and improve patient outcomes. Traditional systems of medicine, notably Ayurveda, offer holistic approaches diabetes management, with focus on natural remedies lifestyle modifications. Shilajatu, mineral-rich substance derived from the Himalayan mountains, holds particular significance in Ayurvedic practice has been studied for its potential regulating levels. This research paper explores Shilajatu's therapeutic optimal individuals diabetes, investigating biochemical composition, mechanisms action, clinical evidence supporting efficacy. Additionally, study delves into principles relevant highlighting interplay between dietary patterns, choices, application herbal remedies. By synergizing traditional wisdom contemporary biomedical insights employing mathematical modeling techniques, aims provide comprehensive perspective advance care optimize outcomes through integration ancient knowledge modern science.

Language: Английский

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Dissolution Extrusion Film Dynamics: Elucidating Film Characteristics and Fluid Dynamics Behavior

Journal of Research in Science and Engineering, Journal Year: 2025, Volume and Issue: 7(3), P. 9 - 15

Published: March 14, 2025

This research paper investigates the intricate interplay between molecular speed and squeeze dynamics within thin films. Utilizing Reynolds equation as foundational framework, we delve into hydrodynamic pressure of films subjected to action. Through mathematical derivation analysis, unveil nuanced effects on various layers film, shedding light how these influence distribution. Our findings reveal that increases in film thickness, porosity sliding motion with exhibit differential impacts significant implications for understanding behavior under conditions.

Language: Английский

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Unveiling Capillary-Tissue Fluid Exchange: Understanding Red Blood Cell Deformation in Constricted Vessels and its Clinical Significance

Materials Plus, Journal Year: 2024, Volume and Issue: unknown, P. 91 - 99

Published: June 21, 2024

Capillary-tissue fluid exchange plays a critical role in maintaining tissue homeostasis, and understanding the behavior of red blood cells (RBCs) narrow vessels is fundamental to elucidating this process. This paper explored phenomenon RBC deformation constricted its clinical implications. study delves into intricate dynamics flow within capillaries, particularly focusing on situations where diameter these smaller than that (RBCs). In such confined spaces, proximity between RBCs vessel walls minimal, allowing plasma permeate through. research how various factors, including shape deformed RBCs, their velocity, permeability, influence patterns. It reveals scenarios tissues exhibit lower tends be more uniform, while faster-moving encounter less resistance. By comparing findings with existing models, underscores significance advancing our small vessels. Such insights hold promise for development novel diagnostic tools targeting range diseases. Additionally, discussed relevance deformability pathological conditions, microvascular diseases, ischemia-reperfusion injury, inflammation. Understanding complex interplay deformability, function, disease pathology has significant implications therapeutic strategies capillary-tissue exchange.

Language: Английский

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Dynamic Modeling of Blood Flow and Pressure in the Cardiovascular System

International Journal of Science and Research (IJSR), Journal Year: 2024, Volume and Issue: 13(5), P. 1192 - 1199

Published: May 5, 2024

The cardiovascular system is a complex network of blood vessels responsible for transporting vital nutrients, oxygen, and hormones throughout the body.In this paper, we presented mathematical model simulating flow pressure in system, integrating principles from fluid dynamics vessel mechanics. incorporates continuum equation Navier -Stokes equations to describe behavior, while considering viscoelastic properties walls. Through computational simulations, investigated effects varying density, wall thickness, elasticity on distribution gradients. Our findings provided insights into physiological implications -structure interactions within highlighting importance dynamic modeling research clinical practice.

Language: Английский

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Revolutionizing Risk Assessment: Coronary Artery Calcium Score in Cardiovascular Disease Management

International Journal of Science and Research (IJSR), Journal Year: 2024, Volume and Issue: 13(5), P. 1433 - 1438

Published: May 5, 2024

Cardiovascular diseases (CVDs) remain a leading cause of mortality worldwide, necessitating continual advancements in risk assessment and management strategies. Coronary artery calcium (CAC) scoring has emerged as pivotal tool cardiovascular stratification, particularly for individuals at intermediate risk. This paper explores the transformative role CAC revolutionizing guiding personalized approaches CVD prevention. We delve into principles scoring, its clinical significance, integration current guidelines practices. Additionally, we review evidence supporting efficacy refining prediction, optimizing therapeutic decisions, improving patient outcomes.Furthermore, discuss challenges future directions leveraging to enhance disease management.

Language: Английский

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Investigation of Pulsatile Behavior and Flow Characteristics in Stenosed Arteries: Analysis of Bingham Plastic Fluid Dynamics

International Journal of Science and Research (IJSR), Journal Year: 2024, Volume and Issue: 13(5), P. 394 - 400

Published: May 5, 2024

This work delves into the effects of Bingham plastic fluid flow within stenosed arteries, employing two-layer model to examine pulsatile behavior artery. Utilizing perturbation techniques, study addresses velocity, shear stress, and rate. Graphical representation outcome indicates a decrease in velocity with increasing radius, alongside an increase resistance over time. These findings enhance our understanding dynamics potential implications for diagnosis treatment cardiovascular diseases, particularly atherosclerosis, characterized by plaque buildup arterial blockages. The graphs illustrate that as radius artery increases, decreases. suggests narrower arteries experience faster blood compared wider ones. Additionally, show time, there is arteries. implies stenosis progresses or persists, also increases. Understanding these crucial gaining insights how flows through which relevant diseases such atherosclerosis. Atherosclerosis involves leading narrowing blockage vessels. from this contribute affected narrowing, can inform diagnostic methods strategies diseases. Therapies aimed at reducing managing its may benefit considering

Language: Английский

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Examining the Impact of Acetylsalicylic Acid on Blood Circulation Dynamics: Investigating its Role in Modulating Flow Characteristics and Thrombus Formation

International Journal of Science and Research (IJSR), Journal Year: 2024, Volume and Issue: 13(5), P. 387 - 393

Published: May 5, 2024

This research paper investigated the impact of Acetylsalicylic Acid, on blood circulation dynamics and thrombus formation in arteries with multiple stenoses. Using mathematical model, Herschel-Bulkley fluid, study examined how Acid influences flow characteristics prevents clot formation. The findings reveal that reduces resistance to flow, particularly stenosis, by diluting blood, lowering viscosity, decreasing pressure. Graphical representations validated these compared them previous studies. Overall, highlighted 's potential as a therapeutic agent for managing cardiovascular disorders modulating inhibiting

Language: Английский

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Characterizing Blood Flow in Constricted Radially Non-Symmetric Multiple Stenosed Arteries: A Herschek-Bulkley Fluid Model Approach

International Journal of Science and Research (IJSR), Journal Year: 2024, Volume and Issue: 13(5), P. 1246 - 1252

Published: May 5, 2024

This work delves into the study of blood flow in a complex scenario: two-dimensional model constricted, radially nonsymmetric, multiple stenosed artery. Blood, this case, is modeled as Herschek-Bulkley fluid, with its behavior governed by generalized form Navier-Stokes equation. The set expressions have derived for various characteristics, including resistance to and wall shear stress. Specifically, these characteristics investigated at points maximum depression within single loop stenosis. findings revealed that height stenosis increases, also increases. Additionally, it was observed stress increases axial velocity higher values shape parameter. research sheds light on intricate dynamics arterial geometries, providing insights could be valuable understanding potentially treating conditions related

Language: Английский

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