
NeuroImage, Journal Year: 2024, Volume and Issue: 297, P. 120669 - 120669
Published: June 7, 2024
The relationship between brain entropy (BEN) and early development has been established through animal studies. However, it remains unclear whether the BEN can be used to identify age-dependent functional changes in human neonatal brains genetic underpinning of new neuroimaging marker elucidated. In this study, we analyzed resting-state fMRI data from Developing Human Connectome Project, including 280 infants who were scanned at 37.5-43.5 weeks postmenstrual age. maps calculated for each subject, a voxel-wise analysis was conducted using general linear model examine effects age, sex, preterm birth on BEN. Additionally, evaluated correlation regional gene expression levels. Our results demonstrated that sensorimotor-auditory association cortices, along 'S-A' axis, significantly positively correlated with postnatal age (PNA), negatively gestational (GA), respectively. Meanwhile, right rolandic operculum both GA PNA. Preterm-born exhibited increased values widespread cortical areas, particularly visual-motor cortex, when compared term-born infants. Moreover, identified five BEN-related genes (DNAJC12, FIG4, STX12, CETN2, IRF2BP2), which involved protein folding, synaptic vesicle transportation cell division. These findings suggest fMRI-based serve as an indicator neonates, may influenced by specific genes.
Language: Английский