The Associations Between Individual Anthropometric Measurements and Fracture Risk: A Mendelian Randomization Study DOI
Yucheng Song, Jun Zhou,

Guanghua Tang

et al.

Orthopedics, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 5

Published: Dec. 17, 2024

Background The primary objective of this study was to investigate and substantiate the possible causal connections between measurements body dimensions likelihood experiencing fractures. Materials Methods We employed a two-sample Mendelian randomization (MR) analysis examine associations anthropometric two specific traits—bone mineral density fracture risk. To ensure credibility our conclusions, we used inverse variance weighted (IVW) method along with various sensitivity analyses. Results Our findings suggest notable link increased height Specifically, employing IVW revealed that for every 10-cm increase in height, there 6.0% rise risk (odds ratio [OR], 1.06; 95% CI, 1.06–1.13; P =.0001). This outcome further supported by both weighted-median MR-Egger method, an OR 1.10 (95% 1.03–1.16; =.0003) 1.11 1.08–1.17; =.0020), respectively. No statistically significant were observed other measurements, such as mass index (BMI), waist-to-hip adjusted BMI, hip circumference waist Sensitivity analyses, including regression's intercept test multivariate testing, indicated no substantial presence directional pleiotropy instrumental variables, ensuring stability reliability results. Conclusion MR present genetic evidence supporting distinct factor susceptibility. underscore importance incorporating into development strategies preventing treating osteoporosis. [ Orthopedics . 202x;4x(x):xx–xx.]

Language: Английский

The Associations Between Individual Anthropometric Measurements and Fracture Risk: A Mendelian Randomization Study DOI
Yucheng Song, Jun Zhou,

Guanghua Tang

et al.

Orthopedics, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 5

Published: Dec. 17, 2024

Background The primary objective of this study was to investigate and substantiate the possible causal connections between measurements body dimensions likelihood experiencing fractures. Materials Methods We employed a two-sample Mendelian randomization (MR) analysis examine associations anthropometric two specific traits—bone mineral density fracture risk. To ensure credibility our conclusions, we used inverse variance weighted (IVW) method along with various sensitivity analyses. Results Our findings suggest notable link increased height Specifically, employing IVW revealed that for every 10-cm increase in height, there 6.0% rise risk (odds ratio [OR], 1.06; 95% CI, 1.06–1.13; P =.0001). This outcome further supported by both weighted-median MR-Egger method, an OR 1.10 (95% 1.03–1.16; =.0003) 1.11 1.08–1.17; =.0020), respectively. No statistically significant were observed other measurements, such as mass index (BMI), waist-to-hip adjusted BMI, hip circumference waist Sensitivity analyses, including regression's intercept test multivariate testing, indicated no substantial presence directional pleiotropy instrumental variables, ensuring stability reliability results. Conclusion MR present genetic evidence supporting distinct factor susceptibility. underscore importance incorporating into development strategies preventing treating osteoporosis. [ Orthopedics . 202x;4x(x):xx–xx.]

Language: Английский

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