Navigating the Evolving Landscape of COVID-19: Strategies to Increase Vaccine Confidence and Improve Vaccination Rates in the United States

Published: May 30, 2024

The COVID-19 pandemic has had a significant impact on every individual in the United States. launch of vaccines is estimated to have averted millions deaths and reduced over 18 million related hospitalizations. In September 2023, updated 2023-2024 vaccine that include monovalent component corresponding omicron variant XBB.1.5 reflecting predominant circulating at time strain selection, was approved recommended for use all people ≥ 6 months age. Despite this recommendation, US uptake COVID season been far from optimal, placing many unnecessary risk severe outcomes. This paper provides an overview current state 2023-2024, barriers uptake. With continued evolution virus, potential more virulent variants lower public acceptance vaccination, contributed low are explored, as well provide solutions improving protection future seasons.

Language: Английский

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Patients recovering from COVID-19 who presented with anosmia during their acute episode have behavioral, functional, and structural brain alterations

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Aug. 17, 2024

Patients recovering from COVID-19 commonly exhibit cognitive and brain alterations, yet the specific neuropathological mechanisms risk factors underlying these alterations remain elusive. Given significant global incidence of COVID-19, identifying that can distinguish individuals at developing is crucial for prioritizing follow-up care. Here, we report findings a sample patients consisting 73 adults with mild to moderate SARS-CoV-2 infection without signs respiratory failure 27 infections attributed other agents no history COVID-19. The participants underwent screening, decision-making task, MRI evaluations. We assessed presence anosmia requirement hospitalization. Groups did not differ in age or performance. who presented exhibited more impulsive alternative changes after shift probabilities (r = − 0.26, p 0.001), while required hospitalization showed perseverative choices 0.25, 0.003). Anosmia correlated measures, including decreased functional activity during thinning cortical thickness parietal regions, loss white matter integrity. Hence, could be factor considered when at-risk populations follow-up.

Language: Английский

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Causal association of long COVID with brain structure changes: Findings from a 2-sample Mendelian randomization study

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Nearly 7.5% U.S. adults have long COVID. Recent epidemiological studies indicated that COVID, is significantly associated with subsequent brain structure changes. However, it remains unknown if COVID causally change. Here we applied two Mendelian Randomization (MR) methods - Inverse Variance Weighting MR method (IVW) for correlated instrument variables and Component analysis-based Generalized Method of Moments (PC-GMM) to examine the potential causal relationships from The study was based on an instrumental variable analysis data a recent genome-wide association (GWAS) (3,018 cases 994,582 controls), Enhancing NeuroImaging Genetics through Meta Analysis (ENIGMA) (Global regional cortical measures, N = 33,709; combined hemispheric subcortical volumes, 38,851), UK Biobank (left/right 19,629). We found no significant relationship between As gain more insights into its long-term health outcomes, future works are necessary validate our findings understand mechanisms underlying observed associations, though not causal,

Language: Английский

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Navigating the Evolving Landscape of COVID-19: Strategies to Increase Vaccine Confidence and Improve Vaccination Rates in the United States

Vaccines, Journal Year: 2024, Volume and Issue: 12(9), P. 1072 - 1072

Published: Sept. 19, 2024

The COVID-19 pandemic has had a significant impact on every individual in the United States. launch of vaccines is estimated to have averted millions deaths and reduced over 18 million COVID-19-related hospitalizations. In September 2023, updated 2023–2024 vaccine, which includes monovalent component that corresponds omicron variant XBB.1.5, reflecting predominant circulating at time strain selection, was approved recommended for use all people ≥ 6 months age. Despite this recommendation, US uptake season been far from optimal, placing many unnecessary risk severe outcomes. This paper provides an overview current state barriers vaccine uptake. With continued evolution virus, potential more virulent variants, public acceptance vaccination, contributed low are explored provide solutions improving protection future seasons.

Language: Английский

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Patients Recovering from COVID-19 who Presented Anosmia During their Acute Episode have Behavioral, Functional, and Structural Brain Alterations

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 3, 2024

Abstract Patients recovering from COVID-19 commonly exhibit cognitive and brain alterations, yet the specific neuropathological mechanisms risk factors that underlie these alterations remain elusive. Given significant global incidence of COVID-19, identifying can distinguish individuals at developing medium or long-term is crucial for prioritizing follow-up care. Here, we report findings a sample 100 patients who were affected by respiratory infection during pandemic. This comprised 73 adults with mild to moderate SARS-CoV-2 (who did not require invasive ventilatory assistance) 27 infections attributed other agents no history COVID-19. The participants underwent screening, decision-making task measure flexibility, magnetic resonance imaging evaluations. We assessed two clinical infection: presence anosmia requirement hospitalization due symptoms. Groups differ in age performance, but differentially performance. presented acute episode exhibited more impulsive changes alternatives after shift probabilities task, while required showed perseverative choices. Interestingly, correlated several measures, including decreases functional activity thinning cortical thickness parietal regions, loss white matter integrity corticospinal tracts parietal-thalamic fasciculi, among others. These results suggest could be factor may serve identify at-risk populations follow-up.

Language: Английский

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Dynamics of Changes in the Level of Cognitive Functioning Among Patients After SARS-CoV-2 Infection ‒ A Proposal for Remote Neuropsychological Assessment in a Longitudinal Study

Przegląd Psychologiczny, Journal Year: 2024, Volume and Issue: 67(1), P. 139 - 155

Published: June 27, 2024

Study purpose: The aim of this longitudinal study was to assess the cognitive functioning people who had COVID-19, determine dynamics changes observed in area over a period 3‒4 months, compare patients' results with those control group, and verify usefulness new method remote neuropsychological assessment. Method: A conducted using Brief Test Adult Cognition by Telephone (BTACT) assessment tool, which translated into Polish for purpose study. included subjects following SARS-CoV-2 infection (COVID(+) group) (COVID(‒) group). Cognitive functions both groups were assessed twice, months apart. from July 2020 January 2022. Results: Data comparisons performed mixed ANOVA repeated measures. Compared COVID(‒) COVID(+) group scored significantly lower on first second measurements Backward Digit Span measurement Number Series Test. Additionally, an improvement scores compared in: Rey Auditory-Verbal Learning (RAVLT) immediate delayed recall condition; Test, 30 Seconds Counting Task (30-SACT). Conclusions: obtained show impairment working memory inductive reasoning subjects. In addition, indicates BTACT tracking time individuals infection. Tests (Rey (RAVLT), Test) test (Number appear be particularly useful monitoring mentioned changes.

Language: Английский

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El enigma del coronavirus – Nuevos conocimientos sobre el COVID prolongado – Vacunas

Revista Peruana de Ginecología y Obstetricia, Journal Year: 2024, Volume and Issue: 70(1)

Published: April 3, 2024

Al finalizar el año 2023, parecía que SARS-CoV-2 estaba siendo controlado, aunquesu variante JN.1 infectaba con mayor facilidad, hospitalizaciones de adultosmayores y los no vacunados, pero pocas muertes. Ahora van apareciendo algunasluces sobre COVID prolongado, cómo las secuelas afectan órganos vitales yporqué persisten en un importante número personas. Desafortunadamente, elcerebro es uno más afectados. Por ello, la necesidad vacunas.Consideramos presente actualización al empezar 2024, haciendoun reconocimiento a labor Eric Topol como comunicador científico queproporciona variada información lo viene ocurriendo SARS-CoV-2y COVID-19. Sobre aprendido, aparte prepararnos para futuras pandemias,consideramos evitar soledad, buscar apoyo emocional, practicarla virtualidad telemedicina, seamos creativos, lavémonos manos, usemosmascarilla nos protejan agentes patógenos aéreos apoyemos vacunas.

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