The role of neuroinflammation in PV interneuron impairments in brain networks; implications for cognitive disorders DOI

Pantea Allami,

Niloufar Yazdanpanah,

Nima Rezaei

et al.

Reviews in the Neurosciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Abstract Fast spiking parvalbumin (PV) interneuron is an inhibitory gamma-aminobutyric acid (GABA)ergic diffused in different brain networks, including the cortex and hippocampus. As a key component of PV interneurons collaborate fundamental functions such as learning memory by regulating excitation inhibition (E/I) balance generating gamma oscillations. The unique characteristics interneurons, like their high metabolic demands long branching axons, make them too vulnerable to stressors. Neuroinflammation one most significant stressors that have adverse, long-lasting impact on interneurons. affects through specialized inflammatory pathways triggered cytokines tumor necrosis factor (TNF) interleukin 6 (IL-6). crucial cells neuroinflammation, microglia, also play role. destructive effect inflammation can comprehensive effects cause neurological disorders schizophrenia, Alzheimer’s disease (AD), autism spectrum disorder (ASD), bipolar disorder. In this article, we provide review mechanisms which neuroinflammation leads hypofunction these diseases. integrated knowledge about role cognitive networks involved impairment pathology diseases help us with better therapeutic interventions.

Language: Английский

The role of neuroinflammation in PV interneuron impairments in brain networks; implications for cognitive disorders DOI

Pantea Allami,

Niloufar Yazdanpanah,

Nima Rezaei

et al.

Reviews in the Neurosciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Abstract Fast spiking parvalbumin (PV) interneuron is an inhibitory gamma-aminobutyric acid (GABA)ergic diffused in different brain networks, including the cortex and hippocampus. As a key component of PV interneurons collaborate fundamental functions such as learning memory by regulating excitation inhibition (E/I) balance generating gamma oscillations. The unique characteristics interneurons, like their high metabolic demands long branching axons, make them too vulnerable to stressors. Neuroinflammation one most significant stressors that have adverse, long-lasting impact on interneurons. affects through specialized inflammatory pathways triggered cytokines tumor necrosis factor (TNF) interleukin 6 (IL-6). crucial cells neuroinflammation, microglia, also play role. destructive effect inflammation can comprehensive effects cause neurological disorders schizophrenia, Alzheimer’s disease (AD), autism spectrum disorder (ASD), bipolar disorder. In this article, we provide review mechanisms which neuroinflammation leads hypofunction these diseases. integrated knowledge about role cognitive networks involved impairment pathology diseases help us with better therapeutic interventions.

Language: Английский

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