Multi-omics integration and immune profiling identify possible causal networks leading to uterine microbiome dysbiosis in dairy cows that develop metritis DOI
Segundo Casaro, J.G. Prim, T. D. Gonzalez

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 2, 2024

Abstract Background Cows that develop metritis experience dysbiosis of their uterine microbiome, where opportunistic pathogens overtake commensals. Whether thrive and cause may be determined by how efficiently the immune system responds to these pathogens. Nonetheless, periparturient cows dysregulation, which seems intensified prepartum obesity lipid mobilization Herein, Bayesian networks were applied investigate directional correlations between body weight (BW), BW loss, pre- postpartum systemic profiling plasma metabolome, metabolome microbiome. Results According directionality network, greater led an increase in fatty acids at parturition, indicating heavier lower energy balance than lighter cows. Greater also cellular death, inflammation, activation, metabolomic changes associated with oxidative stress indicates a positive correlation inflammation. These polymorphonuclear cell extravasation postpartum, tissue damage, suggesting excessive migration uterus leads endometrial damage. pathogenic bacteria developed metritis, damage disrupt physical barriers or substrate availability for bacterial growth. Conclusions This work provides robust mechanistic hypotheses impacts peripartum metabolic profiles, leading overgrowth development.

Language: Английский

Multi-omics integration and immune profiling identify possible causal networks leading to uterine microbiome dysbiosis in dairy cows that develop metritis DOI
Segundo Casaro, J.G. Prim, T. D. Gonzalez

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 2, 2024

Abstract Background Cows that develop metritis experience dysbiosis of their uterine microbiome, where opportunistic pathogens overtake commensals. Whether thrive and cause may be determined by how efficiently the immune system responds to these pathogens. Nonetheless, periparturient cows dysregulation, which seems intensified prepartum obesity lipid mobilization Herein, Bayesian networks were applied investigate directional correlations between body weight (BW), BW loss, pre- postpartum systemic profiling plasma metabolome, metabolome microbiome. Results According directionality network, greater led an increase in fatty acids at parturition, indicating heavier lower energy balance than lighter cows. Greater also cellular death, inflammation, activation, metabolomic changes associated with oxidative stress indicates a positive correlation inflammation. These polymorphonuclear cell extravasation postpartum, tissue damage, suggesting excessive migration uterus leads endometrial damage. pathogenic bacteria developed metritis, damage disrupt physical barriers or substrate availability for bacterial growth. Conclusions This work provides robust mechanistic hypotheses impacts peripartum metabolic profiles, leading overgrowth development.

Language: Английский

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