Effect of Probiotics on the Symptomatology of Autism Spectrum Disorder and/or Attention Deficit/Hyperactivity Disorder in Children and Adolescents: Pilot Study DOI Creative Commons
Meritxell Rojo-Marticella, Victoria Arija, Josefa Canals

et al.

Research on Child and Adolescent Psychopathology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 11, 2025

Abstract The aim of this study is to investigate the impact using probiotics with strains related dopamine and gamma-aminobutyric acid production on clinical features autism spectrum disorder (ASD) and/or attention deficit/hyperactivity (ADHD). This randomized, controlled trial involved 38 children ADHD 42 ASD, aged 5–16 years, who received ( Lactiplantibacillus plantarum Levilactobacillus brevis 109/cfu/daily) or placebo for 12 weeks. Parent-reported symptoms were assessed Conners' 3rd-Ed Social Responsiveness Scale Test, 2nd-Ed (SRS-2), completed Conners Continuous Performance (CPT 3) Kiddie CPT, (K-CPT 2). Executive functions, quality life sleep patterns also parent-assessed. Intention-to-treat analyses, controlling sociodemographic nutritional covariates, revealed no significant inter-group differences in parent-reported neuropsychological data after probiotic intervention. However, age-stratified analyses showed improved hyperactivity-impulsivity younger ASD (Cohen’s d = 1.245) 0.692). Intra-group supported these findings aforementioned age intervention group both diagnoses. An improvement impulsivity was observed intra-group analysis CPT commissions scores (probiotic: p 0.001, Cohen’s -1.216; placebo: 0.013, -0.721). A better comfort score (quality life) shown 0.010, 0.722; 0.099, 0.456). used, may improve or/and ASD. Further research warranted explore as an adjunctive therapeutic NDs. Trial registration: clinicaltrials.gov Identifier: NCT05167110.

Language: Английский

Effect of Probiotics on the Symptomatology of Autism Spectrum Disorder and/or Attention Deficit/Hyperactivity Disorder in Children and Adolescents: Pilot Study DOI Creative Commons
Meritxell Rojo-Marticella, Victoria Arija, Josefa Canals

et al.

Research on Child and Adolescent Psychopathology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 11, 2025

Abstract The aim of this study is to investigate the impact using probiotics with strains related dopamine and gamma-aminobutyric acid production on clinical features autism spectrum disorder (ASD) and/or attention deficit/hyperactivity (ADHD). This randomized, controlled trial involved 38 children ADHD 42 ASD, aged 5–16 years, who received ( Lactiplantibacillus plantarum Levilactobacillus brevis 109/cfu/daily) or placebo for 12 weeks. Parent-reported symptoms were assessed Conners' 3rd-Ed Social Responsiveness Scale Test, 2nd-Ed (SRS-2), completed Conners Continuous Performance (CPT 3) Kiddie CPT, (K-CPT 2). Executive functions, quality life sleep patterns also parent-assessed. Intention-to-treat analyses, controlling sociodemographic nutritional covariates, revealed no significant inter-group differences in parent-reported neuropsychological data after probiotic intervention. However, age-stratified analyses showed improved hyperactivity-impulsivity younger ASD (Cohen’s d = 1.245) 0.692). Intra-group supported these findings aforementioned age intervention group both diagnoses. An improvement impulsivity was observed intra-group analysis CPT commissions scores (probiotic: p 0.001, Cohen’s -1.216; placebo: 0.013, -0.721). A better comfort score (quality life) shown 0.010, 0.722; 0.099, 0.456). used, may improve or/and ASD. Further research warranted explore as an adjunctive therapeutic NDs. Trial registration: clinicaltrials.gov Identifier: NCT05167110.

Language: Английский

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