Role of mucous cells in the defence system of the cnidarian Actinia equina (Linnaeus, 1758): The keystone of evolution DOI Open Access
Alessio Alesci, Sebastián Marino,

Anthea Miller

et al.

Acta Zoologica, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Abstract Cnidarians are the first phylum of metazoans to exhibit a functional mucus layer. In evolution, mucous cells perform classical secretory function and act as sentinels for external insults, particularly in mammals. However, this topic has not been much analysed lower metazoans. This study aims investigate role Actinia equina (Anthozoa, Hexacorallia) (Linnaeus, 1758) by using confocal microscopy bioinformatics. The results show colocalization Toll‐like receptor 2 (TLR2) Mucin2 (MUC2) on these cells, suggesting crosstalk between defence response secretion cnidarians. Furthermore, presence TLR2 surface suggests their involvement host responses, occurs vertebrates. Moreover, through silico analysis, we confirmed orthologous genes tested antibodies, providing additional evidence support our from an evolutionary perspective. These data suggest that play defensive throughout helping us understand how have developed adapted across phylogenesis. information also provides new insights into strategies invertebrates clarifies history.

Language: Английский

Role of mucous cells in the defence system of the cnidarian Actinia equina (Linnaeus, 1758): The keystone of evolution DOI Open Access
Alessio Alesci, Sebastián Marino,

Anthea Miller

et al.

Acta Zoologica, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Abstract Cnidarians are the first phylum of metazoans to exhibit a functional mucus layer. In evolution, mucous cells perform classical secretory function and act as sentinels for external insults, particularly in mammals. However, this topic has not been much analysed lower metazoans. This study aims investigate role Actinia equina (Anthozoa, Hexacorallia) (Linnaeus, 1758) by using confocal microscopy bioinformatics. The results show colocalization Toll‐like receptor 2 (TLR2) Mucin2 (MUC2) on these cells, suggesting crosstalk between defence response secretion cnidarians. Furthermore, presence TLR2 surface suggests their involvement host responses, occurs vertebrates. Moreover, through silico analysis, we confirmed orthologous genes tested antibodies, providing additional evidence support our from an evolutionary perspective. These data suggest that play defensive throughout helping us understand how have developed adapted across phylogenesis. information also provides new insights into strategies invertebrates clarifies history.

Language: Английский

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