Exposure to gestational diabetes mellitus in utero impacts hippocampal functional connectivity in response to food cues in children DOI Creative Commons
Sixiu Zhao, Lorenzo Semeia, Ralf Veit

et al.

International Journal of Obesity, Journal Year: 2024, Volume and Issue: 48(12), P. 1728 - 1734

Published: Aug. 28, 2024

Abstract Objectives Intrauterine exposure to gestational diabetes mellitus (GDM) increases the risk of obesity in offspring, but little is known about underlying neural mechanisms. The hippocampus crucial for food intake regulation and vulnerable effects obesity. purpose study was investigate whether GDM affects hippocampal functional connectivity during cues using magnetic resonance imaging (fMRI). Methods Participants were 90 children age 7–11 years (53 females) who underwent an fMRI-based visual cue task fasted state. Hippocampal (FC) examined generalized psychophysiological interaction response versus non-food cues. FC compared between with without exposure, while controlling possible confounding age, sex waist-to-hip ratio. In addition, influence childhood maternal investigated multiple regression models. Results While viewing high caloric cure, exhibited higher insula striatum (i.e., putamen, pallidum nucleus accumbens) unexposed children. With increasing BMI, had lower somatosensory cortex postcentral gyrus). Conclusions associated food-cue induced especially reward processing regions. Future studies longitudinal measurements are needed clarify altered may raise development metabolic diseases later life.

Language: Английский

Exposure to gestational diabetes mellitus in utero impacts hippocampal functional connectivity in response to food cues in children DOI Creative Commons
Sixiu Zhao, Lorenzo Semeia, Ralf Veit

et al.

International Journal of Obesity, Journal Year: 2024, Volume and Issue: 48(12), P. 1728 - 1734

Published: Aug. 28, 2024

Abstract Objectives Intrauterine exposure to gestational diabetes mellitus (GDM) increases the risk of obesity in offspring, but little is known about underlying neural mechanisms. The hippocampus crucial for food intake regulation and vulnerable effects obesity. purpose study was investigate whether GDM affects hippocampal functional connectivity during cues using magnetic resonance imaging (fMRI). Methods Participants were 90 children age 7–11 years (53 females) who underwent an fMRI-based visual cue task fasted state. Hippocampal (FC) examined generalized psychophysiological interaction response versus non-food cues. FC compared between with without exposure, while controlling possible confounding age, sex waist-to-hip ratio. In addition, influence childhood maternal investigated multiple regression models. Results While viewing high caloric cure, exhibited higher insula striatum (i.e., putamen, pallidum nucleus accumbens) unexposed children. With increasing BMI, had lower somatosensory cortex postcentral gyrus). Conclusions associated food-cue induced especially reward processing regions. Future studies longitudinal measurements are needed clarify altered may raise development metabolic diseases later life.

Language: Английский

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