SARS-CoV-2 Infection Is Associated with an Accelerated eGFR Decline in Kidney Transplant Recipients up to Four Years Post Infection

Diagnostics, Journal Year: 2025, Volume and Issue: 15(9), P. 1091 - 1091

Published: April 25, 2025

Background/Objectives: Although kidney transplant recipients (KTRs) who are immune-compromised have been shown to be at high risk of adverse acute COVID-19 outcomes (i.e., mortality and critical illness), the long-term KTRs with a history SARS-CoV-2 infection unknown. We aimed compare without exposure SARS-CoV-2. Methods: This study retrospectively evaluated 1815 in Montefiore Health System from 4 January 2001 31 2024. The final cohorts consisted survived (n = 510) matched 510, controls). Outcomes were defined as all-cause changes estimated glomerular filtration rate (eGFR) urine protein creatinine ratio (UPCR) 30 days up four years post index date. Kaplan–Meier survival analysis Cox proportional modeling performed for mortality. Generalized estimating equations used analyze eGFR UPCR across time. Results: There was no significant group difference (adjusted hazard 0.66, [0.43, 1.01] p 0.057). controls patients before similarly decreased −0.98 units/year [−1.50, −0.46]. By contrast, declined significantly greater (−1.80 [−2.45, −1.15]) after compared COVID-19. association only seen among male not female KTRs. status associated change or rejection rate. Conclusions: an accelerated decline infection, suggesting potential implications graft health. These findings underscore importance vigilant monitoring management function this vulnerable population.

Language: Английский

Long-Term Outcomes of Patients with Pre-Existing Essential Tremor After SARS-CoV-2 Infection

Diagnostics, Journal Year: 2024, Volume and Issue: 14(24), P. 2774 - 2774

Published: Dec. 10, 2024

Although COVID-19 has been linked to worse outcomes in patients with neurological disorders, its impact on those essential tremor (ET) remains unclear. To investigate clinical of ET and without three a half years post-pandemic. 1074 were evaluated this retrospective study the Montefiore Health System from January 2016 July 2023. Comparisons between positive SARS-CoV-2 polymerase chain reaction test made. Outcomes included post-index date major adverse cardiovascular events (MACEs), new-onset sleep disturbances, fatigue, dyspnea, first-time fall, anxiety, depression, headache, imbalance, mild cognitive impairment, all-cause mortality, adjusted hazard ratios (aHR) adjusting for covariates calculated. had higher prevalence pre-existing type-2 diabetes, anxiety compared COVID-19. was significantly associated risk MACEs, (aHR = 2.39 [1.49, 3.82]), disturbance, 2.12 [1.44, 3.13]), 1.83 [1.27, 2.65]), 1.98 [1.40, 2.80]), 4.76 [2.24, 10.14]), 3.66 [2.02, 6.64]), 2.38 [1.20, 4.70]). not mortality. In ET, increases several long-term health outcomes, but

Language: Английский