The role of the early-life gut microbiome in childhood asthma DOI Creative Commons
Ulrika Boulund, Jonathan Thorsen, Urvish Trivedi

et al.

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 30, 2025

Asthma is a chronic disease affecting millions of children worldwide, and in severe cases requires hospitalization. The etiology asthma multifactorial, caused by both genetic environmental factors. In recent years, the role early-life gut microbiome relation to has become apparent, supported an increasing number population studies, vivo research, intervention trials. Numerous factors, which for decades have been associated with risk developing childhood asthma, are now being linked through alterations microbiome. These factors include cesarean birth, antibiotic use, breastfeeding, having siblings or pets, among others. Association studies highlighted several specific microbes that altered but these can vary between phenotype. This demonstrates importance microbial ecosystem necessity well-designed validate underlying mechanisms guide future clinical applications. this review, we examine current literature on identify research gaps allow microbial-focused therapeutic applications asthma.

Language: Английский

The role of the early-life gut microbiome in childhood asthma DOI Creative Commons
Ulrika Boulund, Jonathan Thorsen, Urvish Trivedi

et al.

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 30, 2025

Asthma is a chronic disease affecting millions of children worldwide, and in severe cases requires hospitalization. The etiology asthma multifactorial, caused by both genetic environmental factors. In recent years, the role early-life gut microbiome relation to has become apparent, supported an increasing number population studies, vivo research, intervention trials. Numerous factors, which for decades have been associated with risk developing childhood asthma, are now being linked through alterations microbiome. These factors include cesarean birth, antibiotic use, breastfeeding, having siblings or pets, among others. Association studies highlighted several specific microbes that altered but these can vary between phenotype. This demonstrates importance microbial ecosystem necessity well-designed validate underlying mechanisms guide future clinical applications. this review, we examine current literature on identify research gaps allow microbial-focused therapeutic applications asthma.

Language: Английский

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