Wastewater-based genomic surveillance of SARS-CoV-2 in vulnerable communities in Mumbai DOI Open Access
Pratibha Kadam,

Tejal Mestry,

Nerges Mistry

et al.

The Indian Journal of Medical Research, Journal Year: 2025, Volume and Issue: 160, P. 570 - 577

Published: Jan. 8, 2025

Background & objectives The global impact of COVID-19, with over 45 million cases and 533,300 deaths in India alone, necessitates effective surveillance methods. Traditional approaches face challenges detecting pre-symptomatic asymptomatic cases, prompting the exploration wastewater-based epidemiology (WBE). This study focuses on Mumbai's vulnerable slums, aiming to assess potential WBE as an alternative method. Methods Genomic SARS-CoV-2 was conducted settings (slums) for 11 months (August 2022 June 2023). Wastewater samples from open drains sewage treatment plants were correlated reported COVID-19 city. Early detection emerging viral variants seasonal variations load explored. Results Correlations identified between wastewater early occurring three weeks before clinical diagnoses, underscoring utility WBE. sequencing provided insights into variants, identifying shifts predominant variants. Seasonal showed higher concentrations summer monsoon, potentially associated accelerated droplet evaporation droplet-based transmission during mid-summer monsoon. Interpretation conclusions Wastewater-based emerges a cost-effective rapid warning system, providing crucial virus behaviour evolution. Particularly significant countries like India, aids outbreak monitoring targeted interventions. integration emphasizes its importance comprehensive pandemic monitoring, establishing it integral component public health strategies worldwide.

Language: Английский

Wastewater-based genomic surveillance of SARS-CoV-2 in vulnerable communities in Mumbai DOI Open Access
Pratibha Kadam,

Tejal Mestry,

Nerges Mistry

et al.

The Indian Journal of Medical Research, Journal Year: 2025, Volume and Issue: 160, P. 570 - 577

Published: Jan. 8, 2025

Background & objectives The global impact of COVID-19, with over 45 million cases and 533,300 deaths in India alone, necessitates effective surveillance methods. Traditional approaches face challenges detecting pre-symptomatic asymptomatic cases, prompting the exploration wastewater-based epidemiology (WBE). This study focuses on Mumbai's vulnerable slums, aiming to assess potential WBE as an alternative method. Methods Genomic SARS-CoV-2 was conducted settings (slums) for 11 months (August 2022 June 2023). Wastewater samples from open drains sewage treatment plants were correlated reported COVID-19 city. Early detection emerging viral variants seasonal variations load explored. Results Correlations identified between wastewater early occurring three weeks before clinical diagnoses, underscoring utility WBE. sequencing provided insights into variants, identifying shifts predominant variants. Seasonal showed higher concentrations summer monsoon, potentially associated accelerated droplet evaporation droplet-based transmission during mid-summer monsoon. Interpretation conclusions Wastewater-based emerges a cost-effective rapid warning system, providing crucial virus behaviour evolution. Particularly significant countries like India, aids outbreak monitoring targeted interventions. integration emphasizes its importance comprehensive pandemic monitoring, establishing it integral component public health strategies worldwide.

Language: Английский

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