Overdoses with Xylazine and Fentanyl Recorded in Pennsylvania’s Overdose Information Network DOI Creative Commons
Manuel Cano, David T. Zhu, Yesenia Aponte-Meléndez

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 30, 2024

This study explored whether law enforcement/first responder-reported fentanyl overdose response actions (such as administration of the opioid reversal agent naloxone) differed between overdoses in which xylazine was, versus was not, suspected to be co-involved. Data were drawn from Pennsylvania State Police's Overdose Information Network (ODIN) for 11,478 fentanyl-involved overdoses, 137 reportedly co-involving xylazine, recorded across Pennsylvania, excluding Philadelphia, January 2018-January 16, 2025. We used relative frequencies, Fisher's exact tests, and binomial logistic regression compare first responders' cases Naloxone administered at scene 46.0% involving vs. 67.3% reported fentanyl-no-xylazine overdoses. Multivariable results (among ODIN, adjusting age, sex, race/ethnicity, year, county rurality, other drugs involved) indicated that co-involvement associated with 60% lower odds naloxone (Adjusted Odds Ratio, 0.40; 95% Confidence Interval, 0.28-0.57). Observed differences based on support importance equipping responders tools training recognize/manage distinct challenges xylazine-fentanyl-involved overdose.

Language: Английский

Overdoses with Xylazine and Fentanyl Recorded in Pennsylvania’s Overdose Information Network DOI Creative Commons
Manuel Cano, David T. Zhu, Yesenia Aponte-Meléndez

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 30, 2024

This study explored whether law enforcement/first responder-reported fentanyl overdose response actions (such as administration of the opioid reversal agent naloxone) differed between overdoses in which xylazine was, versus was not, suspected to be co-involved. Data were drawn from Pennsylvania State Police's Overdose Information Network (ODIN) for 11,478 fentanyl-involved overdoses, 137 reportedly co-involving xylazine, recorded across Pennsylvania, excluding Philadelphia, January 2018-January 16, 2025. We used relative frequencies, Fisher's exact tests, and binomial logistic regression compare first responders' cases Naloxone administered at scene 46.0% involving vs. 67.3% reported fentanyl-no-xylazine overdoses. Multivariable results (among ODIN, adjusting age, sex, race/ethnicity, year, county rurality, other drugs involved) indicated that co-involvement associated with 60% lower odds naloxone (Adjusted Odds Ratio, 0.40; 95% Confidence Interval, 0.28-0.57). Observed differences based on support importance equipping responders tools training recognize/manage distinct challenges xylazine-fentanyl-involved overdose.

Language: Английский

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