Protective Impacts of Quercetin and Echinochrome on Female Fertility and Pregnancy Outcomes in Polycystic Ovary Syndrome in Rats DOI

Rokia Gamal Mohamed,

Ayman Saber Mohamed, Ahmed Imam Dakrory

et al.

Birth Defects Research, Journal Year: 2025, Volume and Issue: 117(5)

Published: May 1, 2025

ABSTRACT Background Polycystic ovary syndrome (PCOS) is a universal reproductive, endocrine, and metabolic disorder. It affects 9.2% of women worldwide. Echinochrome (Ech) the most common dark red pigment sea urchin shells possesses high antioxidant hypoglycemic properties. Quercetin (Quer) flavonol widely distributed in plants with Therefore, Ech Quer as combined protective therapy were investigated against letrozole high‐fat diet‐induced PCOS model rats. Methods Sixty female rats divided randomly into five groups: Control: received 2% DMSO normal diet, PCOS: HFD, Ech: Quer: + letrozole, Ech, together daily orally for 4 weeks. Half each group sacrificed, remaining examined their ability to mate fertility. Results treatment restored levels lipid hormonal profiles, oxidative status, kidney liver functions marked amelioration ovarian, uterine histopathology, good evidence pregnancy analysis. Conclusion found have potent effect PCOS, minimal side effects, improved progeny outcomes

Language: Английский

Protective Impacts of Quercetin and Echinochrome on Female Fertility and Pregnancy Outcomes in Polycystic Ovary Syndrome in Rats DOI

Rokia Gamal Mohamed,

Ayman Saber Mohamed, Ahmed Imam Dakrory

et al.

Birth Defects Research, Journal Year: 2025, Volume and Issue: 117(5)

Published: May 1, 2025

ABSTRACT Background Polycystic ovary syndrome (PCOS) is a universal reproductive, endocrine, and metabolic disorder. It affects 9.2% of women worldwide. Echinochrome (Ech) the most common dark red pigment sea urchin shells possesses high antioxidant hypoglycemic properties. Quercetin (Quer) flavonol widely distributed in plants with Therefore, Ech Quer as combined protective therapy were investigated against letrozole high‐fat diet‐induced PCOS model rats. Methods Sixty female rats divided randomly into five groups: Control: received 2% DMSO normal diet, PCOS: HFD, Ech: Quer: + letrozole, Ech, together daily orally for 4 weeks. Half each group sacrificed, remaining examined their ability to mate fertility. Results treatment restored levels lipid hormonal profiles, oxidative status, kidney liver functions marked amelioration ovarian, uterine histopathology, good evidence pregnancy analysis. Conclusion found have potent effect PCOS, minimal side effects, improved progeny outcomes

Language: Английский

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