Unraveling TRPV1’s Role in Cancer: Expression, Modulation, and Therapeutic Opportunities with Capsaicin DOI Creative Commons

Subramanyam Reddy Chinreddy,

Nicole Tendayi Mashozhera,

Badraldeen Rashrash

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(19), P. 4729 - 4729

Published: Oct. 7, 2024

Cancer is a global health challenge with rising incidence and mortality rates, posing significant concerns. The World Health Organization reports cancer as leading cause of death worldwide, contributing to nearly one in six deaths. pathogenesis involves disruptions cellular signaling pathways, resulting uncontrolled cell growth metastasis. Among emerging players biology, Transient Receptor Potential (TRP) channels, notably TRPV1, have garnered attention due their altered expression cells roles tumorigenesis progression. also known the capsaicin receptor, pivotal pain mediation, offering promise therapeutic target. Activation TRPV1 triggers calcium influx affects linked death. Additionally, implicated cancer-induced chemo-sensitivity, upregulation observed sensory neurons innervating oral cancers. Also, when capsaicin, compound from chili peppers, interacts it elicits "hot" sensation influences processes through influx. Understanding TRPV1's multifaceted may lead novel strategies for managing cancer-related symptoms improving patient outcomes. current review elucidates comprehensive role therapy, particularly channel, highlighting its effects various via different pathways discussing limitations.

Language: Английский

Unraveling TRPV1’s Role in Cancer: Expression, Modulation, and Therapeutic Opportunities with Capsaicin DOI Creative Commons

Subramanyam Reddy Chinreddy,

Nicole Tendayi Mashozhera,

Badraldeen Rashrash

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(19), P. 4729 - 4729

Published: Oct. 7, 2024

Cancer is a global health challenge with rising incidence and mortality rates, posing significant concerns. The World Health Organization reports cancer as leading cause of death worldwide, contributing to nearly one in six deaths. pathogenesis involves disruptions cellular signaling pathways, resulting uncontrolled cell growth metastasis. Among emerging players biology, Transient Receptor Potential (TRP) channels, notably TRPV1, have garnered attention due their altered expression cells roles tumorigenesis progression. also known the capsaicin receptor, pivotal pain mediation, offering promise therapeutic target. Activation TRPV1 triggers calcium influx affects linked death. Additionally, implicated cancer-induced chemo-sensitivity, upregulation observed sensory neurons innervating oral cancers. Also, when capsaicin, compound from chili peppers, interacts it elicits "hot" sensation influences processes through influx. Understanding TRPV1's multifaceted may lead novel strategies for managing cancer-related symptoms improving patient outcomes. current review elucidates comprehensive role therapy, particularly channel, highlighting its effects various via different pathways discussing limitations.

Language: Английский

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